Gavin Irvine, Stuart Herron, Daniel W. Lester, Efrosyni Themistou
{"title":"Acid-labile and non-degradable cross-linked star polymer model networks by aqueous polymerization for in situ encapsulation and release","authors":"Gavin Irvine, Stuart Herron, Daniel W. Lester, Efrosyni Themistou","doi":"10.1039/d3py00677h","DOIUrl":null,"url":null,"abstract":"Biocompatible, acid-labile cross-linked star polymer model networks (CSPMNs) have a great potential for use in drug delivery. However, a primary complication of this research stems from the prevalence for their synthesis to take place in organic solvents. Herein, to minimize CSPMN potential cytotoxicity, aqueous reversible addition-fragmentation chain transfer polymerization is employed for their synthesis. Initially, “arm-first” star polymers were synthesized in water using poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) homopolymer and, non-degradable ethylene glycol dimethacrylate or acid-labile diacetal-based bis[(2-methacryloyloxy)ethoxymethyl] ether cross-linker. Subsequently, OEGMA addition resulted in preparation of “in-out” star polymers (with higher molecular weights) followed by cross-linker addition to form CSPMNs. Rhodamine B dye encapsulation was performed during CSPMN synthesis and its release was observed in biologically relevant conditions. Having shown the effective breakdown of the diacetal-based CSPMNs, their potential for use in drug delivery in low pH environments (i.e. cancerous tumors) is expected to be high.","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d3py00677h","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
Biocompatible, acid-labile cross-linked star polymer model networks (CSPMNs) have a great potential for use in drug delivery. However, a primary complication of this research stems from the prevalence for their synthesis to take place in organic solvents. Herein, to minimize CSPMN potential cytotoxicity, aqueous reversible addition-fragmentation chain transfer polymerization is employed for their synthesis. Initially, “arm-first” star polymers were synthesized in water using poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA) homopolymer and, non-degradable ethylene glycol dimethacrylate or acid-labile diacetal-based bis[(2-methacryloyloxy)ethoxymethyl] ether cross-linker. Subsequently, OEGMA addition resulted in preparation of “in-out” star polymers (with higher molecular weights) followed by cross-linker addition to form CSPMNs. Rhodamine B dye encapsulation was performed during CSPMN synthesis and its release was observed in biologically relevant conditions. Having shown the effective breakdown of the diacetal-based CSPMNs, their potential for use in drug delivery in low pH environments (i.e. cancerous tumors) is expected to be high.
期刊介绍:
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.