Bioreactors: A Regenerative Approach to Skeletal Muscle Engineering for Repair and Replacement

IF 4 Q2 ENGINEERING, BIOMEDICAL
Alysha Williamson, Khashayar Khoshmanesh, Elena Pirogova, Peiqi Yang, Finn Snow, Richard Williams, Anita Quigley, Rob M. I. Kapsa
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Abstract

Engineering skeletal muscle tissue is crucial for the repair and replacement of damaged or dysfunctional muscle. Despite numerous studies emphasizing the significance of skeletal muscle engineering, challenges persist in effectively replacing or repairing large muscle sections in vivo. Bioreactors that facilitate the rapid expansion of muscle precursor cells present a promising solution for addressing extensive muscle loss. Specifically, bioreactors that mimic the native microenvironment of muscle tissue can induce biomimetic stimuli, selectively promoting the expansion of muscle precursors with optimal myo-regenerative potential. In this review, the advancements made in utilizing bioreactors to enhance the myo-regenerative phenotype of cells for skeletal muscle engineering are highlighted.

Abstract Image

生物反应器:用于修复和替代的骨骼肌工程再生方法
骨骼肌组织工程对于修复和替代受损或功能障碍的肌肉至关重要。尽管大量研究强调了骨骼肌工程的重要性,但在体内有效替代或修复大块肌肉方面仍存在挑战。能促进肌肉前体细胞快速扩增的生物反应器为解决肌肉大面积缺失问题提供了一种前景广阔的解决方案。具体来说,模拟肌肉组织原生微环境的生物反应器可诱导生物模拟刺激,选择性地促进具有最佳肌肉再生潜能的肌肉前体细胞扩增。本综述将重点介绍利用生物反应器增强骨骼肌工程细胞的肌再生表型所取得的进展。
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来源期刊
Advanced Nanobiomed Research
Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-
CiteScore
5.00
自引率
5.90%
发文量
87
审稿时长
21 weeks
期刊介绍: Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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