Development of multi-herbal formulation with enhanced antimicrobial, antioxidant, cytotoxic, and antiaging properties

IF 3.2 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2024-09-30 DOI:10.1016/j.jics.2024.101402

Rex Jeya Rajkumar Samdavid Thanapaul , Chandresh Kumar Nambur , Kalaiarasi Giriraj

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Abstract

We developed a multi-herbal formulation (MCCSSTAMP) containing Mentha piperita, Allium sativum, Syzygium aromaticum, Curcuma longa, Syzygium cumini, Trigonella foenum-graecum, Coriandrum sativum, Murraya koenigii and Piper nigrum which was found to be versatile for the development of novel medicines and cosmetic products. The formulation was prepared using a hydro-alcoholic base and its phytochemical composition was analyzed. The initial phytochemical analysis revealed that MCCSSTAMP contained various phytochemicals, with the highest concentrations of phenolic content. The antimicrobial, anti-oxidant, cytotoxic, and anti-aging properties of the MCCSSTAMP were explored. The formulation showed potent anti-microbial efficacy against various microorganisms, including antibiotic-resistant strains. MCCSSTAMP also demonstrated potent anti-oxidant activity, effectively scavenging free radicals and chelating metal ions. Furthermore, it exhibited cytotoxic activity against carcinoma cell lines, comparable to a standard chemotherapeutic agent cisplatin. The formulation has a potential anti-aging agent and skin-whitening additive due to its significant inhibitory activity against enzymes involved in the aging process, such as hyaluronidase, elastase, and tyrosinase. Our study claims that the efficacy was attributed to the synergistic effect of combining multiple herbs in the formulation. Further, it acted as a viable source of nutritional supplements for the nutraceutical industry, as all of the plants used in the formulation are edible, making it a promising candidate for cancer treatment research and its application in cosmetic products to address hyperpigmentation and maintain skin integrity.

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开发具有更强抗菌、抗氧化、细胞毒性和抗衰老特性的多种草药配方

我们开发了一种多草药配方（MCCSSTAMP），其中含有薄荷、薤白、芳香茜草、莪术、孜然茜草、白茅、芫荽、鹅掌楸和胡椒，该配方可用于开发新型药物和化妆品。使用水醇基制备了配方，并对其植物化学成分进行了分析。初步的植物化学分析显示，MCCSSTAMP 含有多种植物化学物质，其中酚含量最高。研究还探讨了 MCCSSTAMP 的抗菌、抗氧化、细胞毒性和抗衰老特性。该制剂对各种微生物（包括抗生素耐药菌株）具有很强的抗微生物功效。MCCSSTAMP 还具有强大的抗氧化活性，能有效清除自由基和螯合金属离子。此外，它还具有抗癌细胞株的细胞毒性活性，可与标准化疗药物顺铂相媲美。该制剂对参与衰老过程的酶，如透明质酸酶、弹性蛋白酶和酪氨酸酶具有显著的抑制活性，因此具有抗衰老和美白添加剂的潜力。我们的研究表明，这种功效归功于配方中多种草药的协同作用。此外，由于配方中使用的所有植物均可食用，它还是营养保健品行业的一种可行的营养补充剂来源，因此有望用于癌症治疗研究，并应用于化妆品中，以解决色素沉着问题并保持皮肤完整性。

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来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.