Synthesis and evaluation of iron oxide nanoparticles from banana peel (Musa spp.) extract for the delivery of ciprofloxacin against resistant Escherichia coli

IF 3.2 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society Pub Date : 2024-09-23 DOI:10.1016/j.jics.2024.101393

{"title":"Synthesis and evaluation of iron oxide nanoparticles from banana peel (Musa spp.) extract for the delivery of ciprofloxacin against resistant Escherichia coli","authors":"","doi":"10.1016/j.jics.2024.101393","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objective</h3><div>Resistance to antimicrobials is one of our most significant worldwide challenges. In Africa, around 31 % of the infections of urinary tract (UTIs) initiated by <em>Escherichia coli</em> (<em>E. coli</em>) have been observed to develop ciprofloxacin (CIP) resistance. As a result, significant efforts have been made to investigate novel and improved antibiotics. This study aimed at synthesizing iron oxide nanoparticles (IONPs) using banana peels (<em>Musa Spp</em>.) extract for delivery of CIP against resistant <em>E. coli</em>.</div></div><div><h3>Methods</h3><div>A green synthesis method was used for the synthesis of IONPs using FeCl<sub>3</sub>.6H<sub>2</sub>O as a precursor and banana peel extract as a reducing and stabilizing agent. The physicochemical characteristics of the formed nanoparticles (NPs) were characterized using different methods.</div></div><div><h3>Results</h3><div>The formation of hematite (α-Fe<sub>2</sub>O<sub>3</sub>) was confirmed with its FTIR characteristic peak at 461 cm<sup>−1</sup>, 542 cm<sup>−1</sup>, and 1131 cm<sup>−1</sup>. The size of synthesized IONPs was found to be 10.4 nm <span><math><mrow><mo>±</mo></mrow></math></span> 1.98, 48 nm <span><math><mrow><mo>±</mo></mrow></math></span> 0.9, and 67.3 nm <span><math><mrow><mo>±</mo></mrow></math></span> 0.9 under XRD, SEM, and DLS measurements respectively. CIP-IONPs had almost the maximum drug loading capacity (33.3 % <span><math><mrow><mo>±</mo></mrow></math></span> 0.67) with fast and slow drug release patterns at gastric and intestinal or blood pH respectively, and it had a promising resistant reversal with a zone of inhibition (ZOI) 22 mm ± 0.15 against resistance <em>E. coli</em>.</div></div><div><h3>Conclusion</h3><div>The green synthesis of IONP using banana peel extract represents a novel and eco-friendly approach for the delivery of ciprofloxacin, with potential applications in addressing antimicrobial resistance.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Indian Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0019452224002735","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and objective

Resistance to antimicrobials is one of our most significant worldwide challenges. In Africa, around 31 % of the infections of urinary tract (UTIs) initiated by Escherichia coli (E. coli) have been observed to develop ciprofloxacin (CIP) resistance. As a result, significant efforts have been made to investigate novel and improved antibiotics. This study aimed at synthesizing iron oxide nanoparticles (IONPs) using banana peels (Musa Spp.) extract for delivery of CIP against resistant E. coli.

Methods

A green synthesis method was used for the synthesis of IONPs using FeCl₃.6H₂O as a precursor and banana peel extract as a reducing and stabilizing agent. The physicochemical characteristics of the formed nanoparticles (NPs) were characterized using different methods.

Results

The formation of hematite (α-Fe₂O₃) was confirmed with its FTIR characteristic peak at 461 cm⁻¹, 542 cm⁻¹, and 1131 cm⁻¹. The size of synthesized IONPs was found to be 10.4 nm

\pm

1.98, 48 nm

\pm

0.9, and 67.3 nm

\pm

0.9 under XRD, SEM, and DLS measurements respectively. CIP-IONPs had almost the maximum drug loading capacity (33.3 %

\pm

0.67) with fast and slow drug release patterns at gastric and intestinal or blood pH respectively, and it had a promising resistant reversal with a zone of inhibition (ZOI) 22 mm ± 0.15 against resistance E. coli.

Conclusion

The green synthesis of IONP using banana peel extract represents a novel and eco-friendly approach for the delivery of ciprofloxacin, with potential applications in addressing antimicrobial resistance.

查看原文本刊更多论文

从香蕉皮（麝香草属）提取物中合成氧化铁纳米颗粒并对其进行评估，用于对耐药性大肠杆菌施用环丙沙星

背景和目的抗菌药耐药性是我们面临的最重大的全球性挑战之一。在非洲，由大肠埃希氏菌（E. coli）引发的泌尿道（UTI）感染中约有 31% 出现了环丙沙星（CIP）耐药性。因此，人们一直在努力研究新型和改良抗生素。本研究旨在利用香蕉皮（麝香草属）提取物合成氧化铁纳米粒子（IONPs），用于对耐药性大肠杆菌施用环丙沙星。方法以 FeCl3.6H2O 为前体，香蕉皮提取物为还原剂和稳定剂，采用绿色合成法合成 IONPs。结果赤铁矿（α-Fe2O3）的傅立叶红外光谱特征峰在 461 cm-1、542 cm-1 和 1131 cm-1 处，证实了赤铁矿的形成。通过 XRD、SEM 和 DLS 测量发现，合成的 IONPs 尺寸分别为 10.4 nm ± 1.98、48 nm ± 0.9 和 67.3 nm ± 0.9。CIP-IONPs 几乎具有最大的载药量（33.3 % ± 0.67），在胃和肠道或血液 pH 值下分别具有快速和缓慢的药物释放模式，对耐药性大肠杆菌的抑制区（ZOI）为 22 mm ± 0.15，具有良好的耐药性逆转效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of the Indian Chemical Society 化学-化学综合

CiteScore

3.50

自引率

7.70%

发文量

492

审稿时长

3-8 weeks

期刊介绍： The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.