Synthesis and evaluation of iron oxide nanoparticles from banana peel (Musa spp.) extract for the delivery of ciprofloxacin against resistant Escherichia coli
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引用次数: 0
Abstract
Background and objective
Resistance to antimicrobials is one of our most significant worldwide challenges. In Africa, around 31 % of the infections of urinary tract (UTIs) initiated by Escherichia coli (E. coli) have been observed to develop ciprofloxacin (CIP) resistance. As a result, significant efforts have been made to investigate novel and improved antibiotics. This study aimed at synthesizing iron oxide nanoparticles (IONPs) using banana peels (Musa Spp.) extract for delivery of CIP against resistant E. coli.
Methods
A green synthesis method was used for the synthesis of IONPs using FeCl3.6H2O as a precursor and banana peel extract as a reducing and stabilizing agent. The physicochemical characteristics of the formed nanoparticles (NPs) were characterized using different methods.
Results
The formation of hematite (α-Fe2O3) was confirmed with its FTIR characteristic peak at 461 cm−1, 542 cm−1, and 1131 cm−1. The size of synthesized IONPs was found to be 10.4 nm 1.98, 48 nm 0.9, and 67.3 nm 0.9 under XRD, SEM, and DLS measurements respectively. CIP-IONPs had almost the maximum drug loading capacity (33.3 % 0.67) with fast and slow drug release patterns at gastric and intestinal or blood pH respectively, and it had a promising resistant reversal with a zone of inhibition (ZOI) 22 mm ± 0.15 against resistance E. coli.
Conclusion
The green synthesis of IONP using banana peel extract represents a novel and eco-friendly approach for the delivery of ciprofloxacin, with potential applications in addressing antimicrobial resistance.
期刊介绍:
The Journal of the Indian Chemical Society publishes original, fundamental, theorical, experimental research work of highest quality in all areas of chemistry, biochemistry, medicinal chemistry, electrochemistry, agrochemistry, chemical engineering and technology, food chemistry, environmental chemistry, etc.