Fabrication, microstructure and hemostatic activity of Cu-Zn manganite nanoparticles

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY

Results in Chemistry Pub Date : 2024-10-01 DOI:10.1016/j.rechem.2024.101841

H. Shashidharagowda , Shridhar Mathad , Shridhar Malladi , C.G. Kusuma , Vinod Gubbiveeranna , S. Nagaraju , H. Ravi Kumar , Sahebagouda Jambaladinni , Huda Wazzan , Anish Khan , Khalid A Alzahrani , Hadi M Marwani , Mohammad A. Wazzan , Asmaa M. Malash

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Abstract

Copper subbed zinc manganite Zn(1-x)CuxMn₂O₄ (x = 0.05,0.15,0.25,0.35,0.45,0.55) (BCZMO) NPs were prepared by sol–gel co-precipitation technique at surrounding temperature. BCZMO NPs were analyzed by XRD, SEMfor microstructure characterizations. XRD study confirms the tetragon structure of BCZMO NPs and effect of copper on ZMO NPs. SEM micrographs supports our findings. The BCZMO NPs interfered in blood coagulation and exhibited pro-coagulant property. BCZMO NPs decreased the coagulation time of citrated plasma from control 4.31 min to 1.35 min. In addition, the BCZMO NPs aggregated platelets up to 80 % at a concentration of 600 µg while the agonist epinephrine prompted platelet collection of around 90 % at 10 mM concentration.No kind of hemolytic activity in RBC cells shown by these BCZMO-NPs insisting their non-toxic nature. These BCZMO-NPs exhibited pro-coagulant effect with their interference in blood coagulation cascade and initiation in platelet aggregation. Thus, BCZMO NPs can be a potential candidate in biomedical field as hemostatic agents.

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铜锌锰矿纳米粒子的制备、微观结构和止血活性

采用溶胶-凝胶共沉淀技术在常温下制备了铜基锌锰矿 Zn(1-x)CuxMn2O4 (x = 0.05,0.15,0.25,0.35,0.45,0.55) (BCZMO) NPs。对 BCZMO NPs 的微观结构特征进行了 XRD 和 SEM 分析。XRD 研究证实了 BCZMO NPs 的四方结构以及铜对 ZMO NPs 的影响。扫描电镜显微照片证实了我们的发现。BCZMO NPs干扰了血液凝固并表现出促凝特性。BCZMO NPs 可将柠檬酸血浆的凝固时间从对照组的 4.31 分钟缩短至 1.35 分钟。此外，浓度为 600 µg 的 BCZMO NPs 可使血小板聚集达 80%，而浓度为 10 mM 的激动剂肾上腺素可使血小板聚集约 90%。这些 BCZMO-NPs 具有促凝作用，能干扰血液凝固级联反应并引发血小板聚集。因此，BCZMO NPs 有可能成为生物医学领域的止血剂。

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