A simple and highly efficient catalyst-free for the synthesis of dihydro pyrido[1, 2-a]quinoxaline derivatives by four component reactions and evaluation of their antibacterial activity

IF 2.5 Q2 CHEMISTRY, MULTIDISCIPLINARY
Mahmoud Nassiri , Jaber Salehzadeh , Forough Jalili Milani , Parisa Babaei
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引用次数: 0

Abstract

In the current work, a new series of methyl-10-amino-9-cyano-6-oxo-8-aryl-6,8-dihydro-5H-pyrido[1,2-a]quinoxaline-7-carboxylate derivatives were efficiently designed and prepared using a convenient route in excellent yields by four-component reactions among benzene-1,2-diamine, dimethyl acetylenedicarboxylate, various aromatic aldehydes and malononitrile. These reactions were carried out in acetonitrile at ambient temperature under catalyst-free conditions for 7 h. The structures of the new obtained compounds were confirmed by NMR, IR, EI-MS and elemental analysis. The antibacterial activity of the synthesized products was studied using bacterial strains: Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. The results showed that all the synthesized compounds are effective against Staphylococcus aureus, Bacillus subtilis and Escherichia coli bacteria.

Abstract Image

通过四组分反应合成二氢吡啶并[1, 2-a]喹喔啉衍生物的简单高效无催化剂方法及其抗菌活性评价
本研究采用简便的路线,通过苯-1,2-二胺、乙炔二甲酸二甲酯、多种芳香醛和丙二腈的四组分反应,有效地设计和制备了一系列新的甲基-10-氨基-9-氰基-6-氧代-8-芳基-6,8-二氢-5H-吡啶并[1,2-a]喹喔啉-7-羧酸酯衍生物,并获得了优异的产率。通过核磁共振、红外光谱、电离质谱和元素分析确认了新化合物的结构。利用细菌菌株对合成产物的抗菌活性进行了研究:金黄色葡萄球菌、枯草杆菌、大肠杆菌和绿脓杆菌。结果表明,所有合成化合物都对金黄色葡萄球菌、枯草杆菌和大肠杆菌有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Results in Chemistry
Results in Chemistry Chemistry-Chemistry (all)
CiteScore
2.70
自引率
8.70%
发文量
380
审稿时长
56 days
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