Neural underpinnings of a two-phase memory suppression process in the neural response to self-related and observed perspective views

IF 5.3 1区 心理学 Q1 PSYCHOLOGY, CLINICAL
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引用次数: 0

Abstract

Individuals often actively suppress intrusive memories to alleviate the distress they cause and maintain mental well-being. However, those with post-traumatic stress disorder (PTSD) often exhibit difficulties particularly in inhibiting or suppressing negative memories compared to individuals without PTSD. These memories can involve a physical threat either to the individual themselves or to others. Unfortunately, there is still limited understanding of the cognitive and neural mechanisms that underlie how suppression differs for self-related versus other-related memories. Here we capitalized on multivariate pattern analyses in combination with fMRI data acquired during a two-phase memory suppression paradigm where participants volitionally suppressed and subsequently recognized self-related and other-related stimuli. The results suggested that the recognition process following memory suppression demands more cognitive engagement for self-related stimuli than other-related stimuli, manifesting in increased activity in the dorsal anterior cingulate cortex (dACC). Furthermore, after memory suppression, we observed a stronger functional coupling between dACC identified during memory suppression, and both the middle frontal gyrus and the insula during self-related recognition compared to other-related recognition. An advanced multivariate pattern analysis substantiated that the limbic system and empathy network particularly contributed to accurately distinguishing between self-related and other-related recognition following memory suppression. Our findings demonstrated distinct neural representations of memory suppression related to self and others, suggesting that different strategies may be employed for suppressing intrusive memories originating from different sources.
自我相关视角和观察视角神经反应中两阶段记忆抑制过程的神经基础
个人通常会积极抑制侵入性记忆,以减轻其带来的痛苦并保持心理健康。然而,与没有创伤后应激障碍的人相比,患有创伤后应激障碍(PTSD)的人在抑制或压制负面记忆方面往往表现得尤为困难。这些记忆可能涉及对自己或他人的身体威胁。遗憾的是,人们对自我相关记忆和他人相关记忆的抑制有何不同的认知和神经机制的了解仍然有限。在这里,我们利用多变量模式分析,结合在两阶段记忆抑制范式中获得的 fMRI 数据,让参与者自愿抑制并随后识别自我相关和他人相关的刺激。结果表明,记忆抑制后的识别过程中,自我相关刺激比其他相关刺激需要更多的认知参与,表现为背侧前扣带回皮层(dACC)的活动增加。此外,在记忆抑制后,我们观察到在记忆抑制过程中识别出的 dACC 与在自我相关识别过程中识别出的额叶中回和岛叶之间的功能耦合比与其他相关识别过程中的功能耦合更强。一项先进的多元模式分析证实,边缘系统和移情网络尤其有助于在记忆抑制后准确区分自我相关识别和他人相关识别。我们的研究结果表明,与自我和他人相关的记忆抑制有不同的神经表征,这表明在抑制来自不同来源的侵入性记忆时可能会采用不同的策略。
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来源期刊
CiteScore
10.70
自引率
5.70%
发文量
38
审稿时长
33 days
期刊介绍: The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.
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