Exploring the gut microbiota of rural region of Haryana (India): sociodemographic, socioeconomic factors and lifestyle

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2024-10-05 DOI:10.1016/j.cegh.2024.101806

Suchandra Gupta , Manisha Khandait , Sandhya Khunger

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引用次数: 0

Abstract

Background

The normal gut microbiota serves numerous functions in our body, which includes metabolism of food and drugs, maintenance of integrity of mucosal barrier and also protection against pathogens. Various factors are responsible in designing the structure of gut microbiota such as diet, lifestyle, sociodemographic and socioeconomic factors. The aim of the research was to study the composition of gut microbiota of individuals from rural regions of Haryana and to understand the impact of sociodemographic factors, lifestyle, and socioeconomic status on the diversity of gut microbiota.

Methods

A cross-sectional study was conducted on 200 healthy individuals from rural region of Haryana, data pertaining to their socioeconomic and sociodemographic factors, lifestyle and diet was recorded through a questionnaire, followed by the processing of stool samples by both culture-dependent and independent techniques.

Results

Out of the 200 samples, the abundance of phylum Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria were found. High alpha diversity with less beta diversity was observed. High counts of Lactobacillus, Bifidobacterium and Prevotella were found among males, whereas among females high abundance of Fusobacterium, Streptococcus, Enterococcus and E.coli were found. Occupation wise we found increased abundance of Bifidobacterium, Clostridium, Bacteroides, Rhuminicoccus and Salmonella in homemakers, whereas among employed subjects abundance of Lactobacillus and Yersinia were increased. Presence of butyrate producing bacteria (Bifidobacterium and Lactobacillus) among the subjects with sufficient sleep was also recorded.

Conclusion

While comparing the association of gut microbiota with various sociodemographic factors, we found differences in the phylum abundance, but statistically it was nonsignificant. Whereas positive association was observed between gut microbiota and healthy lifestyle which includes consumption of balanced diet, non smokers, sufficient water intake and good quality of sleep.

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探索哈里亚纳邦（印度）农村地区的肠道微生物群：社会人口、社会经济因素和生活方式

背景正常的肠道微生物群在人体内发挥着多种功能，包括食物和药物的新陈代谢、维护粘膜屏障的完整性以及抵御病原体。设计肠道微生物群结构的因素有很多，如饮食、生活方式、社会人口和社会经济因素。本研究旨在研究哈里亚纳邦农村地区个体的肠道微生物群组成，并了解社会人口因素、生活方式和社会经济状况对肠道微生物群多样性的影响。方法对来自哈里亚纳邦农村地区的 200 名健康人进行了横断面研究，通过问卷调查记录了他们的社会经济和社会人口因素、生活方式和饮食习惯等相关数据，然后通过依赖培养技术和独立技术处理粪便样本。观察到α多样性较高，β多样性较低。男性中乳酸杆菌、双歧杆菌和普雷沃特氏菌的数量较高，而女性中镰刀菌、链球菌、肠球菌和大肠杆菌的数量较高。从职业角度看，我们发现家庭主妇中的双歧杆菌、梭状芽孢杆菌、乳酸杆菌、Rhuminicoccus 和沙门氏菌的数量增加，而就业者中的乳酸杆菌和耶尔森氏菌的数量增加。结论在比较肠道微生物群与各种社会人口学因素的关联时，我们发现了菌门丰度的差异，但在统计学上并不显著。而肠道微生物群与健康的生活方式（包括均衡饮食、不吸烟、充足的水摄入量和良好的睡眠质量）之间存在正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.