Adherence to antiretroviral therapy among HIV patients at a hospital in Tacna, Peru

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2024-10-08 DOI:10.1016/j.cegh.2024.101803

Brayan Miranda-Chavez , Monica Mejia-Copaja , Alvaro Taype-Rondan

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Abstract

Objective

This study aims to provide an overview of antiretroviral therapy adherence and its related factors within a hospital in southern Peru.

Materials and methods

We conducted an analytical cross-sectional study spanning from April to October 2022. This study involved a review of medical records and the administration of a survey to individuals living with Human Immunodeficiency Virus. Adherence to antiretroviral treatment was assessed using the CEAT-HIV (Questionnaire for the Evaluation of Antiretroviral Treatment Adherence), and was categorized as high, adequate, insufficient, or low. The statistical analysis included the calculation of crude and adjusted prevalence ratios (PRs).

Results

Our study comprised 300 participants, with a median age of 30 years, predominantly male (78.3 %). Among these individuals, 83 % exhibited low or insufficient adherence to antiretroviral treatment according to the CEAT-VIH scale. Notably, patients with a viral load >50,000 copies/ml scored higher on the CEAT-VIH scale than those with a viral load <400 (adjusted PR: 2.78, 95 % CI: 1.21 to 6.40). Furthermore, a higher level of education and a viral load below 400 copies/ml were associated to higher scores in the treatment compliance dimension of the CEAT-VIH scale.

Conclusion

Eight out of ten evaluated patients exhibited low or insufficient adherence. While lower adherence was correlated with lower education, the connection between viral load and adherence remains inconclusive.

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秘鲁塔克纳一家医院的艾滋病患者坚持抗逆转录病毒治疗的情况

材料与方法我们在 2022 年 4 月至 10 月期间开展了一项横断面分析研究。这项研究包括审查医疗记录和对人类免疫缺陷病毒感染者进行调查。使用 CEAT-HIV（抗逆转录病毒治疗依从性评估问卷）评估抗逆转录病毒治疗的依从性，并将其分为 "高"、"足够"、"不足 "或 "低"。统计分析包括计算粗略患病率比（PRs）和调整患病率比（PRs）。结果我们的研究有 300 名参与者，中位年龄为 30 岁，以男性为主（78.3%）。根据 CEAT-VIH 量表，其中 83% 的患者对抗逆转录病毒治疗的依从性较低或不足。值得注意的是，病毒载量为 50,000 拷贝/毫升的患者在 CEAT-VIH 量表上的得分高于病毒载量为 400 拷贝/毫升的患者（调整后 PR：2.78，95 % CI：1.21 至 6.40）。此外，教育程度越高、病毒载量低于 400 copies/ml 的患者在 CEAT-VIH 量表的治疗依从性维度上得分越高。虽然较低的依从性与较低的教育程度相关，但病毒载量与依从性之间的关系仍不确定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.