Incidence and risk factors of silent deep venous thromboembolism before interval debulking surgery in ovarian cancer patients, a tertiary centre experience

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports Pub Date : 2024-10-06 DOI:10.1016/j.gore.2024.101522

Mohamed Abdelkhalek, Basel Refky, Mohammed Zuhdy, Omar Hamdy, Mohamed Hamdy, Khaled Gaballa, Amr Elalfy

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引用次数: 0

Abstract

Objective

To determine the prevalence and risk factors for the development of asymptomatic venous thromboembolism (VTE) in ovarian cancer patients who underwent interval cytoreductive surgery after finishing neoadjuvant chemotherapy.

Methods

This is a prospective observational trial. Female patients with pathologically proven ovarian cancer who received neoadjuvant chemotherapy without clinical evidence of VTE were included.

Results

A total of 107 patients were enrolled in this study. The mean age was 53.37 years, and the mean body mass index (BMI) was 34.11 kg/m². Seven (6.5 %) patients suffered from silent VTE, as documented by bilateral Doppler ultrasound in the pre- and postoperative settings. The mean age of the patients in the VTE group was 56.17 years, and their mean body mass index was 31.71 Kg/m². Their median serum CA125 concentration was elevated (325.6 units/ml). On the other hand, the median D-dimer level was elevated by 678 ng/ml fibrinogen equivalent units (FEUs) in the same group of patients. In the present study, comorbidities did not influence the incidence of VTE, as the 7 patients who were diagnosed with VTE did not have any comorbidities. Most of the patients who were diagnosed with serous adenocarcinoma (71.4 %) or stage IIIc disease (57.1 %) were most likely to develop VTE.

Conclusion

Silent VTE is more prevalent in patients with advanced-stage ovarian cancer and serous carcinomas.

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卵巢癌患者间歇性去势手术前无声深静脉血栓栓塞症的发病率和风险因素，一家三级中心的经验

目的探讨卵巢癌患者在完成新辅助化疗后接受间歇性细胞减灭术时发生无症状静脉血栓栓塞（VTE）的发生率和风险因素。纳入的病理证实为卵巢癌的女性患者均接受了新辅助化疗，且无 VTE 临床证据。平均年龄为 53.37 岁，平均体重指数 (BMI) 为 34.11 kg/m2。术前和术后双侧多普勒超声检查显示，7 名患者（6.5%）患有无声 VTE。VTE 组患者的平均年龄为 56.17 岁，平均体重指数为 31.71 公斤/平方米。他们的血清 CA125 浓度中位数偏高（325.6 单位/毫升）。另一方面，同组患者的中位 D-二聚体水平升高了 678 纳克/毫升纤维蛋白原当量单位（FEUs）。在本研究中，合并症并不影响 VTE 的发病率，因为确诊为 VTE 的 7 名患者没有任何合并症。大多数确诊为浆液性腺癌（71.4%）或 IIIc 期疾病（57.1%）的患者最有可能发生 VTE。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic Oncology Reports OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

183

审稿时长

41 days

期刊介绍： Gynecologic Oncology Reports is an online-only, open access journal devoted to the rapid publication of narrative review articles, survey articles, case reports, case series, letters to the editor regarding previously published manuscripts and other short communications in the field of gynecologic oncology. The journal will consider papers that concern tumors of the female reproductive tract, with originality, quality, and clarity the chief criteria of acceptance.