Investigating the effect of whey and casein proteins on drug solubility from a paediatric drug absorption perspective

IF 5.2 2区医学 Q1 PHARMACOLOGY & PHARMACY

International Journal of Pharmaceutics: X Pub Date : 2024-10-09 DOI:10.1016/j.ijpx.2024.100290

Matthias Van der Veken , Joachim Brouwers , Neil Parrott , Patrick Augustijns , Cordula Stillhart

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引用次数: 0

Abstract

Considering the predominantly milk-based diet of neonates and infants and their immature gastrointestinal digestion, milk proteins may affect drug behaviour and absorption in this population. Using in vitro models, this study investigated the impact of the representative milk proteins, whey and casein, on the solubility and permeation of the lipophilic model drugs spironolactone, clopidogrel and ritonavir. Drug solubility experiments revealed that the presence of milk proteins increased drug solubility. Next, permeation studies demonstrated that the same milk proteins reduced drug permeation across an artificial membrane. These results highlight the importance of the solubility-permeability interplay and indicate the effect of these proteins may be considered during (paediatric) drug development. Lastly, the findings underscore the importance of considering milk protein-drug interactions to optimize drug delivery strategies during (paediatric) drug development and especially for the youngest and most vulnerable part of this population.

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从儿科药物吸收角度研究乳清蛋白和酪蛋白对药物溶解度的影响

考虑到新生儿和婴儿的饮食主要以牛奶为主，而且他们的胃肠道消化功能尚未成熟，牛奶蛋白可能会影响药物在这一人群中的行为和吸收。本研究利用体外模型，研究了代表性牛奶蛋白（乳清蛋白和酪蛋白）对亲脂性模型药物螺内酯、氯吡格雷和利托那韦的溶解度和渗透性的影响。药物溶解度实验表明，牛奶蛋白的存在增加了药物的溶解度。接下来的渗透研究表明，同样的牛奶蛋白降低了药物在人工膜上的渗透。这些结果突显了溶解度和渗透性相互作用的重要性，并表明在（儿科）药物开发过程中可以考虑这些蛋白质的影响。最后，研究结果强调了在开发（儿科）药物过程中考虑牛奶蛋白与药物相互作用以优化给药策略的重要性，尤其是对这一人群中最年轻和最脆弱的部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Pharmaceutics: X Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

24 days

期刊介绍： International Journal of Pharmaceutics: X offers authors with high-quality research who want to publish in a gold open access journal the opportunity to make their work immediately, permanently, and freely accessible. International Journal of Pharmaceutics: X authors will pay an article publishing charge (APC), have a choice of license options, and retain copyright. Please check the APC here. The journal is indexed in SCOPUS, PUBMED, PMC and DOAJ. The International Journal of Pharmaceutics is the second most cited journal in the "Pharmacy & Pharmacology" category out of 358 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.