End-to-end synaptic molecular communication with astrocytic feedback and generic three-state receptors

IF 2.9 4区计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Nano Communication Networks Pub Date : 2024-09-30 DOI:10.1016/j.nancom.2024.100546

Tooba Khan , Muhammad Hanif , Omer Waqar

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Abstract

This paper investigates the mutual information of synaptic molecular communications using a realistic end-to-end synaptic model. In particular, we have considered the influence of astrocytes on neural signaling within the synaptic molecular communication. We have evaluated the average mutual information of the resultant tripartite synapse while considering realistic synaptic geometry that accounts for neurotransmitter reflections from the pre-synaptic and post-synaptic boundaries. The clearance of neurotransmitters from the synapse through diffusion and re-absorption by pre-synaptic terminal is also considered in the simulated model. Moreover, we have used a generic three-state model for postsynaptic receptors to include desensitization state of the receptors. The presented simulation results depict the effects of different pre-synaptic and post-synaptic parameters on the information transfer for a tripartite synaptic channel with three-state receptor model, which is more realistic than the commonly-used bipartite synaptic channel with the two-state receptor model.

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带有星形胶质细胞反馈和通用三态受体的端到端突触分子通信

本文利用一个逼真的端到端突触模型研究了突触分子通信的互信息。我们特别考虑了突触分子通讯中星形胶质细胞对神经信号的影响。我们评估了由此产生的三方突触的平均互信息，同时考虑了现实的突触几何形状，即突触前和突触后边界的神经递质反射。模拟模型还考虑了神经递质通过突触前终端的扩散和再吸收从突触中清除的问题。此外，我们还使用了突触后受体的通用三态模型，以包括受体的脱敏状态。模拟结果描述了三态受体模型的三方突触通道中，不同的突触前和突触后参数对信息传递的影响，这比常用的双方突触通道和双态受体模型更符合实际情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Communication Networks Mathematics-Applied Mathematics

CiteScore

6.00

自引率

6.90%

发文量

期刊介绍： The Nano Communication Networks Journal is an international, archival and multi-disciplinary journal providing a publication vehicle for complete coverage of all topics of interest to those involved in all aspects of nanoscale communication and networking. Theoretical research contributions presenting new techniques, concepts or analyses; applied contributions reporting on experiences and experiments; and tutorial and survey manuscripts are published. Nano Communication Networks is a part of the COMNET (Computer Networks) family of journals within Elsevier. The family of journals covers all aspects of networking except nanonetworking, which is the scope of this journal.