“2+1B” Technetium-99m Tricarbonyl Complexes with N,N'-Bidentate Ligands and Methyl 14-Isocyano-3-methyltetradecanoate

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Radiochemistry Pub Date : 2024-10-06 DOI:10.1134/S1066362224040143

A. E. Miroslavov, P. M. Kuz’menko, M. Yu. Tyupina, A. P. Sakhonenkova, G. V. Sidorenko, A. R. Kochergina, S. A. Krotov

引用次数: 0

Abstract

A novel 12-step procedure was developed for preparing methyl 14-isocyano-3-methyltetradecanoate. “2+1_B” tricarbonyl complexes [^99mTc(CO)₃(N^N)CN(CH₂)₁₁CH(CH₃)CH₂COOMe]⁺, where N^N = 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [^99mTc(CO)₃(N^N)(H₂O,EtOH)]⁺ with methyl 14-isocyano-3-methyltetradecanoate in aqueous ethanol. The formation of technetium-99m complexes was confirmed by HPLC, and the partition coefficient (n-octanol/water) of these complexes was measured.

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具有 N,N'-三价配体和 14-异氰基-3-甲基十四酸甲酯的 "2+1B "锝-99m 三羰基配合物

为制备 14-异氰基-3-甲基十四酸甲酯开发了一种新型的 12 步程序。通过[99mTc(CO)3(N^N)(H2O,EtOH)]+与 14-异氰基-3-甲基十四酸甲酯在乙醇水溶液中的反应，制备了 "2+1B "三羰基络合物[99mTc(CO)3(N^N)CN(CH2)11CH(CH3)CH2COOMe]+，其中 N^N = 2,2'- 联吡啶（bipy）或 1,10-菲罗啉（phen）。高效液相色谱法证实了锝-99m 复合物的形成，并测量了这些复合物的分配系数（正辛醇/水）。

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来源期刊

Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-

CiteScore

1.30

自引率

33.30%

发文量

期刊介绍： Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.