Isoniazid Analogs and Their Biological Activities as Antitubercular Agents (A Review)

IF 0.9 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Russian Journal of General Chemistry Pub Date : 2024-10-04 DOI:10.1134/S1070363224080231

S. Alghamdi, N. F. Qusty, B. Atwah, Z. Alhindi, R. Alatawy, S. Verma, M. Asif

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引用次数: 0

Abstract

Tuberculosis (TB), which has been a scourge of humanity for thousands of years, is a worldwide pandemic disease caused mainly by M. tuberculosis (Mtb). The appearance of TB and the emergence of drug resistance (DR) requires focused attention and the need to approve the various isoniazid (INH) analogs. The DR-TB, multidrug resistance (MDR), extensively drug-resistant (XDR), and totally drug-resistant (TDR) TB increase the challenges to eliminate TB globally. INH is an important heterocyclic moiety in medicinal chemistry due to the presence of an active site, which extends its applications and is a frontline key anti-TB drug. In this review, we aim to summarize synthetic strategies and pharmacological properties of INH analogs and we also discussed INH analogs as potent anti-TB agents. This review summarized the recent advances of anti-TB agents holding INH as a nucleus. Data on collection of various INH analogs and their biological activities like anti-TB, antibacterial, antifungal, antiviral, etc. were presented.

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异烟肼类似物及其作为抗结核药物的生物活性（综述）

结核病（TB）几千年来一直祸害人类，是一种主要由结核杆菌（Mtb）引起的世界性流行病。结核病的出现和耐药性（DR）的出现需要重点关注，需要批准各种异烟肼（INH）类似物。DR-TB、耐多药（MDR）、广泛耐药（XDR）和完全耐药（TDR）结核病增加了在全球消除结核病的挑战。INH 是药物化学中一个重要的杂环分子，因为它存在一个活性位点，从而扩大了其应用范围，是一线关键抗结核药物。在这篇综述中，我们总结了 INH 类似物的合成策略和药理特性，并讨论了作为强效抗结核药物的 INH 类似物。本综述总结了以 INH 为核心的抗结核药物的最新进展。介绍了各种 INH 类似物的收集数据及其生物活性，如抗结核、抗菌、抗真菌、抗病毒等。

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来源期刊

Russian Journal of General Chemistry 化学-化学综合

CiteScore

1.40

自引率

22.20%

发文量

252

审稿时长

2-4 weeks

期刊介绍： Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.