Water soluble azide functionalized cobalt oxide nanoparticles

IF 2.1 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2024-10-03 DOI:10.1007/s11051-024-06134-9

Christian Scott, Sophia Miller, Pierre Moënne-Loccoz, Craig Eliot Barnes, Martina Ralle

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Abstract

The synthesis of water-soluble nanoparticles is a well-developed field for ferrite-based nanoparticles with the majority consisting of iron oxide or mixed metal iron oxide nanoparticles. However, the synthesis of non-agglomerated non-ferrite metal or metal oxide NPs is not as well established. The synthesis and characterization of uniform 20 nm, water-soluble cobalt oxide (CoO) nanoparticles (NPs) is described. These nanoparticles have two principle components: (1) a CoO core of suitable size to contain enough cobalt atoms to be visualized by X-ray fluorescence microscopy (XFM) and (2) a robust coating that inhibits NP aggregation as well as renders them water-soluble. Stable cobalt oxide NPs are initially obtained with octadecyl amine coatings as reported by Bhattacharjee. Two strategies for solubilizing these NPs in water were investigated with varying degrees of success. Exchanging the octadecyl amine coating for a nitrodopamine anchored PEG coating yielded the desired water-soluble NPs but in very low yield. Alternately, leaving the octadecyl amine coating on the NPs and interdigitating this with a maleic anhydride-vinyl copolymer with different hydrophobic sidechains followed by opening the maleic anhydride ring with amine substituted PEG polymers (the water solubilizing component), yielded the desired water-soluble NPs in good yield. Characterization data for the nanoparticles and the components of the coatings required for bioorthogonal reactions to ligate them with biotargeting agents are also described.

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水溶性叠氮化物功能化氧化钴纳米粒子

水溶性纳米粒子的合成是铁氧体基纳米粒子的一个成熟领域，其中大部分由氧化铁或混合金属氧化铁纳米粒子组成。然而，非团聚的非铁氧体金属或金属氧化物 NPs 的合成技术还不成熟。本文介绍了 20 纳米水溶性均匀氧化钴（CoO）纳米粒子（NPs）的合成和表征。这些纳米粒子有两个主要成分：(1) 大小合适的 CoO 核心，含有足够的钴原子，可通过 X 射线荧光显微镜 (XFM) 观察到；(2) 可抑制 NP 聚集并使其具有水溶性的坚固涂层。根据 Bhattacharjee 的报告，稳定的氧化钴 NP 最初是通过十八烷基胺涂层获得的。研究人员研究了两种使这些 NPs 溶于水的策略，并取得了不同程度的成功。将十八烷基胺涂层换成硝基多巴胺锚定 PEG 涂层，可以获得所需的水溶性 NPs，但产量非常低。另一种方法是，在 NPs 上保留十八烷基胺涂层，并与具有不同疏水侧链的马来酸酐-乙烯共聚物相互结合，然后用胺取代的 PEG 聚合物（水溶性成分）打开马来酸酐环，这样就能得到所需的水溶性 NPs，而且产量很高。此外，还介绍了纳米粒子的表征数据，以及将纳米粒子与生物靶向药剂连接的生物正交反应所需的涂层成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.