Cancer of the paranasal sinuses in Germany: Data on incidence and survival from a population-based cancer registry

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2024-10-10 DOI:10.1016/j.canep.2024.102684

Lisa Nachtsheim , Lennart Möller , Florian Oesterling , Hiltraud Kajueter , Andreas Stang , Lena Hieggelke , Helen Abing , Jenny Shachi Sharma , Jens Peter Klussmann , Marcel Mayer , Philipp Wolber

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引用次数: 0

Abstract

Purpose

This study aims to provide a broad overview of the epidemiology of cancer of the paranasal sinuses (PSC) in Germany. The data include information on incidence, staging, clinicopathological features and survival from one of the largest cancer registries in Europe.

Methods

Population-based data on PSC diagnosed from January 1st, 2009 until December 31st, 2019 were retrieved from the German Centre for Cancer Registry Data (ZfKD). Age standardized incidence was calculated and relative survival estimates were computed by sex, histological subtype, age group and T-, N-, and M-Stage.

Results

In total, 3975 cases were included in this study. The age-adjusted incidence rate (ASR) for PSC was 0.3/100,000 which remained stable during the observation period. The most frequent tumor localization was the maxillary sinus (41.9 %) and the most common histological subtype was keratinizing squamous cell carcinoma (kSCC) (44.3 %). All subtypes were predominantly found in the maxillary sinus except for adenocarcinoma and neuroendocrine carcinomas (SNEC), which were most frequently located in the ethmoidal sinus. The majority of the patients with a known T stage was diagnosed in tumor stage T4 (60.8 %). The overall 5-year relative survival (RS) for all patients with PSC was 52 %. RS dropped from 93 % for T1 stage tumors to 39 % for T4 tumors. RS was 58 % for N0 and 31 % for N+ cases, 54 % for M0 and 27 % for M1 cases.

Conclusion

Age-adjusted incidence for PSC is low and has been stable for the observed 11-year period. RS decreases continuously with increasing T-, N- and M-stage.

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德国的副鼻窦癌症：来自人口癌症登记处的发病率和存活率数据。

目的：本研究旨在概述德国鼻旁窦癌（PSC）的流行病学。数据包括来自欧洲最大的癌症登记处之一的发病率、分期、临床病理特征和存活率等信息：方法：从德国癌症登记数据中心（ZfKD）检索了 2009 年 1 月 1 日至 2019 年 12 月 31 日期间确诊的 PSC 患者的人口数据。按性别、组织学亚型、年龄组以及T期、N期和M期计算了年龄标准化发病率和相对生存率：本研究共纳入 3975 例病例。PSC的年龄调整发病率（ASR）为0.3/100,000，在观察期内保持稳定。最常见的肿瘤部位是上颌窦（41.9%），最常见的组织学亚型是角化鳞状细胞癌（44.3%）。除了腺癌和神经内分泌癌（SNEC）最常见于乙状窦外，所有亚型都主要发生在上颌窦。大多数已知T分期的患者被诊断为肿瘤T4期（60.8%）。所有 PSC 患者的总体 5 年相对生存率（RS）为 52%。相对生存率从 T1 期肿瘤的 93% 降至 T4 期肿瘤的 39%。N0和N+病例的相对生存率分别为58%和31%，M0和M1病例的相对生存率分别为54%和27%：结论：经年龄调整后，PSC 的发病率较低，且在观察的 11 年间保持稳定。随着T、N和M分期的增加，RS持续下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.