The Antibacterial Activities and Effects of Baicalin on Ampicillin Resistance of MRSA and Stenotrophomonas maltophilia.

IF 1.9 2区农林科学 Q3 FOOD SCIENCE & TECHNOLOGY

Foodborne pathogens and disease Pub Date : 2024-10-11 DOI:10.1089/fpd.2024.0074

Kun Chen, Xiaojing Liu, Lin Song, Ying Wang, Jingwen Zhang, Yaxin Song, Haonan Zhuang, Jinling Shen, Jielin Yang, Chuantao Peng, Jinhong Zang, Qingli Yang, Day Li, Tanushree B Gupta, Dehua Guo, Zhaojie Li

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Abstract

The development of novel antibacterial agents from plant sources is emerging as a successful strategy to combat antibiotic resistance in pathogens. In this study, we systemically investigated the antibacterial activity and underlying mechanisms of baicalin against methicillin-resistant Staphylococcus aureus (MRSA) and Stenotrophomonas maltophilia. Our results showed that baicalin effectively restrained bacterial proliferation, compromised the integrity of cellular membranes, increased membrane permeability, and triggered oxidative stress within bacteria. Transcriptome profiling revealed that baicalin disrupted numerous biological pathways related to antibiotic resistance, biofilm formation, cellular membrane permeability, bacterial virulence, and so on. Furthermore, baicalin demonstrated a synergistic antibacterial effect when combined with ampicillin against both MRSA and S. maltophilia. In conclusion, baicalin proves to be a potent antibacterial agent with significant potential for addressing the challenge of antibiotic resistance in pathogens.

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黄芩苷对 MRSA 和嗜麦芽血单胞菌氨苄西林耐药性的抗菌活性和影响

从植物资源中开发新型抗菌剂正在成为对抗病原体抗生素耐药性的一种成功策略。在这项研究中，我们系统地研究了黄芩苷对耐甲氧西林金黄色葡萄球菌（MRSA）和嗜麦芽血单胞菌的抗菌活性及其内在机制。我们的研究结果表明，黄芩苷能有效抑制细菌的增殖，破坏细胞膜的完整性，增加膜的通透性，并引发细菌体内的氧化应激。转录组分析表明，黄芩苷破坏了许多与抗生素耐药性、生物膜形成、细胞膜通透性、细菌毒力等相关的生物通路。此外，黄芩苷与氨苄西林联合使用时，对 MRSA 和嗜麦芽糖酵母菌均有协同抗菌作用。总之，黄芩苷被证明是一种强效抗菌剂，在应对病原体的抗生素耐药性挑战方面具有巨大潜力。

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来源期刊

Foodborne pathogens and disease 医学-食品科技

CiteScore

5.30

自引率

3.60%

发文量

审稿时长

1 months

期刊介绍： Foodborne Pathogens and Disease is one of the most inclusive scientific publications on the many disciplines that contribute to food safety. Spanning an array of issues from "farm-to-fork," the Journal bridges the gap between science and policy to reduce the burden of foodborne illness worldwide. Foodborne Pathogens and Disease coverage includes: Agroterrorism Safety of organically grown and genetically modified foods Emerging pathogens Emergence of drug resistance Methods and technology for rapid and accurate detection Strategies to destroy or control foodborne pathogens Novel strategies for the prevention and control of plant and animal diseases that impact food safety Biosecurity issues and the implications of new regulatory guidelines Impact of changing lifestyles and consumer demands on food safety.