MicroRNA-107 – a small RNA with a big impact on cytokinesis in hepatocellular carcinoma

IF 26.8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Journal of Hepatology Pub Date : 2024-10-11 DOI:10.1016/j.jhep.2024.09.045

Xiaowei Zhong, Michael Ott, Amar Deep Sharma, Asha Balakrishnan

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Abstract

Authors declare no conflict of interest related to this study

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MicroRNA-107--对肝细胞癌细胞分裂有重大影响的小 RNA

作者声明与本研究无利益冲突下载：下载高清图片 (832KB)Download：图 1：miR-107/KIF23 轴是 HCC 发展的关键调控因子在正常肝组织中，高水平的肝细胞富集-miR-107 可抑制 Kif23 翻译。在 HCC 中，MiR-107 表达下调，导致 KIF23 翻译增强。这使得 HCC 细胞异常增殖。过表达 miR-107 或敲除 KIF23 都会导致有丝分裂纺锤体组装失败、细胞分裂失败，进而抑制肿瘤的发展。(图由 BioRender.com 绘制）。

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来源期刊

Journal of Hepatology 医学-胃肠肝病学

CiteScore

46.10

自引率

4.30%

发文量

2325

审稿时长

30 days

期刊介绍： The Journal of Hepatology is the official publication of the European Association for the Study of the Liver (EASL). It is dedicated to presenting clinical and basic research in the field of hepatology through original papers, reviews, case reports, and letters to the Editor. The Journal is published in English and may consider supplements that pass an editorial review.