Au Nanorods Activate Zn2+/Ag+ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2024-09-24 DOI:10.1021/acsmaterialslett.4c0154610.1021/acsmaterialslett.4c01546

Wang Zheng, Hui Shen, Yuanfang Cheng, Litao Liu, Jiangwei Sun, Zhaoyou Chu*, Wanni Wang* and Haisheng Qian*,

{"title":"Au Nanorods Activate Zn2+/Ag+ Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles","authors":"Wang Zheng, Hui Shen, Yuanfang Cheng, Litao Liu, Jiangwei Sun, Zhaoyou Chu*, Wanni Wang* and Haisheng Qian*, ","doi":"10.1021/acsmaterialslett.4c0154610.1021/acsmaterialslett.4c01546","DOIUrl":null,"url":null,"abstract":"Wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have attracted wide attention owing to acidic biofilms and the alkaline wound microenvironment, which result in hindering wound healing. In this work, we prepared an acid–base responsive bionic claw microneedle (MN) loaded with Au@ZnO/Ag (AZA) core–shell nanoparticles, which shows excellent photothermal transition and antibacterial activity. In the acidic medium of the biofilm, 97.98% of bacteria were successfully eradicated under mild thermal conditions (≤40 °C). In the alkaline wound microenvironment, inflammatory cytokines were inhibited by Ag+. Vascular endothelial growth factor expression was promoted by trace Zn2+, and the wound healing rate increased by up to 24.02% compared to the control group. The bionic claw MN loaded with AZA effectively combines the benefits of low-temperature acidic sterilization and alkaline anti-inflammatory activity. The promotion of MRSA infected wound healing through the synergistic effect of released Zn2+/Ag+ and the mild thermal impact showcases new avenues for clinical treatment.","PeriodicalId":19,"journal":{"name":"ACS Materials Letters","volume":"6 10","pages":"4791–4800 4791–4800"},"PeriodicalIF":9.6000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Materials Letters","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsmaterialslett.4c01546","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have attracted wide attention owing to acidic biofilms and the alkaline wound microenvironment, which result in hindering wound healing. In this work, we prepared an acid–base responsive bionic claw microneedle (MN) loaded with Au@ZnO/Ag (AZA) core–shell nanoparticles, which shows excellent photothermal transition and antibacterial activity. In the acidic medium of the biofilm, 97.98% of bacteria were successfully eradicated under mild thermal conditions (≤40 °C). In the alkaline wound microenvironment, inflammatory cytokines were inhibited by Ag⁺. Vascular endothelial growth factor expression was promoted by trace Zn²⁺, and the wound healing rate increased by up to 24.02% compared to the control group. The bionic claw MN loaded with AZA effectively combines the benefits of low-temperature acidic sterilization and alkaline anti-inflammatory activity. The promotion of MRSA infected wound healing through the synergistic effect of released Zn²⁺/Ag⁺ and the mild thermal impact showcases new avenues for clinical treatment.

Abstract Image

查看原文本刊更多论文

金纳米棒激活 Zn2+/Ag+ 介导的抗炎作用，通过仿生爪微针增强耐甲氧西林伤口修复能力

耐甲氧西林金黄色葡萄球菌（MRSA）引起的伤口感染已引起广泛关注，其原因是酸性生物膜和碱性伤口微环境导致伤口愈合受阻。在这项工作中，我们制备了一种酸碱响应型仿生爪微针（MN），其中装载了 Au@ZnO/Ag (AZA) 核壳纳米粒子，显示出优异的光热转换和抗菌活性。在生物膜的酸性介质中，在温和的热条件下（≤40 °C），97.98%的细菌被成功消灭。在碱性伤口微环境中，Ag+ 可抑制炎症细胞因子。痕量 Zn2+ 促进了血管内皮生长因子的表达，与对照组相比，伤口愈合率提高了 24.02%。负载 AZA 的仿生爪 MN 有效地结合了低温酸性杀菌和碱性抗炎活性的优点。通过释放的 Zn2+/Ag+ 和温和的热影响的协同作用，促进了 MRSA 感染伤口的愈合，为临床治疗提供了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.