Assessing the feasibility of anticholinergic burden scales and measures in administrative data: A systematic review

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics Pub Date : 2024-09-30 DOI:10.1016/j.archger.2024.105646

Valentina M. Srikartika , Ninh Ha , David Youens , Rachael Moorin

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引用次数: 0

Abstract

Aim

This systematic review aimed to identify and evaluate the quality and adaptability of existing anticholinergic burden scales and measures by using administrative dispensing data.

Method

A comprehensive literature search was conducted using the Medline, Embase, CINAHL, and Google Scholar databases from 2001 to 2022. Studies that introduced, updated, or modified anticholinergic burden scales and measures were included in this review. Quality assessment considered various aspects, including scoring systems, tool development criteria, and specific requirements tailored for administrative data.

Results

Twenty-eight anticholinergic burden scales and measures were identified in 14 countries. The Modified Anticholinergic Risk Scale excelled in the scoring system, while the German Anticholinergic Burden Scale stood out in the scale development process. However, significant variability was observed in methodologies, medication listings, and adaptability to administrative data. Quality assessment considers aspects such as potency, dose, exposure duration, longitudinal measurement, clinical interpretation, and compatibility with administrative data variables. The evaluation also considered tool development criteria including evidence for medication selection, panel expertise, relevance, updating methods, international applicability, validation, and clinical guidance.

Conclusion

This review emphasizes the importance of adaptable and robust tools that can work well with administrative data to ensure patient safety and better health outcomes, given the ongoing evolution of anticholinergic medications. The findings of this systematic review provide valuable insights for clinicians and researchers in selecting the most appropriate anticholinergic burden scale or measure according to their specific needs and data sources. This systematic review was registered with PROSPERO (registration ID CRD42023423959).

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评估行政数据中抗胆碱能负担量表和措施的可行性：系统综述。

目的：本系统综述旨在通过使用行政配药数据，确定和评估现有抗胆碱能药物负担量表和测量方法的质量和适应性：方法：使用 Medline、Embase、CINAHL 和 Google Scholar 数据库对 2001 年至 2022 年的文献进行了全面检索。本综述纳入了引入、更新或修改抗胆碱能药物负担量表和测量方法的研究。质量评估考虑了各个方面，包括评分系统、工具开发标准以及针对行政数据的具体要求：结果：在 14 个国家发现了 28 种抗胆碱能负担量表和测量方法。改良抗胆碱能风险量表在评分系统中表现突出，而德国抗胆碱能负担量表则在量表开发过程中脱颖而出。不过，在方法、药物清单和行政数据的适应性等方面存在很大差异。质量评估考虑的方面包括药效、剂量、暴露持续时间、纵向测量、临床解释以及与行政数据变量的兼容性。评估还考虑了工具开发标准，包括药物选择证据、专家小组专业知识、相关性、更新方法、国际适用性、验证和临床指导：鉴于抗胆碱能药物的不断发展，本综述强调了适应性强、功能强大的工具的重要性，这些工具可与管理数据完美结合，以确保患者安全和更好的医疗效果。本系统综述的研究结果为临床医生和研究人员提供了宝贵的见解，帮助他们根据具体需求和数据来源选择最合适的抗胆碱能药物负担量表或测量方法。本系统综述已在 PROSPERO 注册（注册编号为 CRD42023423959）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.