Catherine Kelly, Caroline Trumpff, Carlos Acosta, Stephanie Assuras, Jack Baker, Sophia Basarrate, Alexander Behnke, Ke Bo, Natalia Bobba-Alves, Frances A Champagne, Quinn Conklin, Marissa Cross, Philip De Jager, Kris Engelstad, Elissa Epel, Soah G Franklin, Michio Hirano, Qiuhan Huang, Alex Junker, Robert-Paul Juster, Darshana Kapri, Clemens Kirschbaum, Mangesh Kurade, Vincenzo Lauriola, Shufang Li, Cynthia C Liu, Grace Liu, Bruce McEwen, Marlon A McGill, Kathleen McIntyre, Anna S Monzel, Jeremy Michelson, Aric A Prather, Eli Puterman, Xiomara Q Rosales, Peter A Shapiro, David Shire, George M Slavich, Richard P Sloan, Janell L M Smith, Marisa Spann, Julie Spicer, Gabriel Sturm, Sophia Tepler, Michel Thiebaut de Schotten, Tor D Wager, Martin Picard
{"title":"A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: the MiSBIE study.","authors":"Catherine Kelly, Caroline Trumpff, Carlos Acosta, Stephanie Assuras, Jack Baker, Sophia Basarrate, Alexander Behnke, Ke Bo, Natalia Bobba-Alves, Frances A Champagne, Quinn Conklin, Marissa Cross, Philip De Jager, Kris Engelstad, Elissa Epel, Soah G Franklin, Michio Hirano, Qiuhan Huang, Alex Junker, Robert-Paul Juster, Darshana Kapri, Clemens Kirschbaum, Mangesh Kurade, Vincenzo Lauriola, Shufang Li, Cynthia C Liu, Grace Liu, Bruce McEwen, Marlon A McGill, Kathleen McIntyre, Anna S Monzel, Jeremy Michelson, Aric A Prather, Eli Puterman, Xiomara Q Rosales, Peter A Shapiro, David Shire, George M Slavich, Richard P Sloan, Janell L M Smith, Marisa Spann, Julie Spicer, Gabriel Sturm, Sophia Tepler, Michel Thiebaut de Schotten, Tor D Wager, Martin Picard","doi":"10.1016/j.tem.2024.08.006","DOIUrl":null,"url":null,"abstract":"<p><p>Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain-body, and mind-mitochondria processes relevant to medicine and public health.</p>","PeriodicalId":54415,"journal":{"name":"Trends in Endocrinology and Metabolism","volume":" ","pages":"884-901"},"PeriodicalIF":11.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555495/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Endocrinology and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tem.2024.08.006","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/9 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain-body, and mind-mitochondria processes relevant to medicine and public health.
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Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage.
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