Mild behavioral impairment in the general population aged 55+ and its association with incident dementia.

IF 4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2024-10-10 eCollection Date: 2024-10-01 DOI:10.1002/dad2.12610

Patricia Gracia-García, Raúl López-Antón, Concepción de la Cámara, Javier Santabárbara, Elena Lobo, Antonio Lobo

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Abstract

This study aimed to investigate the dementia risk associated with mild behavioral impairment (MBI) and its domains in older community-dwelling individuals. A total 4803 community-dwelling individuals aged over 55 years were followed for 4.5 years (ZARADEMP study). MBI was assessed according to the International Society to Advance Alzheimer's Research and Treatment (ISTAART) diagnostic criteria using the Geriatric Mental State (GMS). Odds ratios (OR) for incident dementia and Alzheimer's disease (AD) were determined using logistic regression models adjusted for potential confounders (such as age, disability, or vascular disease). In cognitively normal individuals, decreased motivation was the only MBI domain that was associated with an increased risk of all-cause dementia (OR: 2.30 [95% confidence interval {CI}: 1.16-4.61]) in multivariable analyses, although the increase in the risk of AD was not statistically significant. Our findings suggest that decreased motivation may be a phenotypic marker for individuals at risk of dementia. Further research is required to evaluate the association between MBI domains and different types of dementia.

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55 岁以上普通人群中的轻度行为障碍及其与痴呆症的关联。

这项研究旨在调查社区老年人中与轻度行为障碍（MBI）及其领域相关的痴呆风险。研究人员对 4803 名 55 岁以上的社区老年人进行了为期 4.5 年的跟踪调查（ZARADEMP 研究）。根据国际老年痴呆症研究和治疗促进会（ISTAART）的诊断标准，使用老年精神状态（GMS）对 MBI 进行了评估。使用逻辑回归模型确定痴呆症和阿尔茨海默病（AD）的发病率比（OR），并对潜在的混杂因素（如年龄、残疾或血管疾病）进行调整。在认知能力正常的个体中，动机下降是唯一一个在多变量分析中与全因痴呆风险增加相关的 MBI 领域（OR：2.30 [95% 置信区间{CI}：1.16-4.61]），尽管 AD 风险的增加在统计学上并不显著。我们的研究结果表明，动机下降可能是痴呆症高危人群的表型标志。还需要进一步的研究来评估MBI领域与不同类型痴呆症之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.