Relevance of combined influence of nutritional and inflammatory status on non-alcoholic fatty liver disease and advanced fibrosis: A mediation analysis of lipid biomarkers.
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引用次数: 0
Abstract
Background and aim: This study aimed to investigate the relationship between advanced lung cancer inflammation index (ALI) and non-alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis (AF).
Methods: A total of 5642 individuals from the National Health and Nutrition Examination Survey (NHANES) between 2017 and 2020 were examined. Limited cubic spline regression model, and weighted logistic regression were employed to determine if ALI levels were related to the prevalence of NAFLD and AF. Additionally, a mediating analysis was conducted to investigate the role of lipid biomarkers, such as total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C), in the effects of ALI on the prevalence of NAFLD and AF.
Results: After adjusting for potential confounders, a significant positive association was found between ALI with NAFLD and AF prevalence. Compared with those in ALI Tertile 1, participants in Tertile 3 had higher odds of NAFLD prevalence (odds ratio [OR]: 3.16; 95% confidence interval [CI]: 2.52-3.97) and AF (OR: 3.17; 95% CI: 2.30-4.36). Participants in both Tertile 2 and Tertile 3 had lower odds of developing AF (P for trend = 0.005). Moreover, we discovered a nonlinear association between ALI and NAFLD. An inflection point of 74.25 for NAFLD was identified through a two-segment linear regression model. Moreover, TC and HDL-C levels mediated the association between ALI and NAFLD by 10.2% and 4.2%, respectively (both P < 0.001).
Conclusion: Our findings suggest that higher ALI levels are positively associated with an increased prevalence of NAFLD and AF, partly mediated by lipid biomarkers.
背景和目的：本研究旨在探讨晚期肺癌炎症指数（ALI）与非酒精性脂肪肝（NAFLD）和晚期肝纤维化（AF）之间的关系：研究对象为2017年至2020年间美国国家健康与营养调查（NHANES）中的5642人。采用有限立方样条回归模型和加权逻辑回归来确定 ALI 水平是否与非酒精性脂肪肝和 AF 患病率相关。此外，还进行了中介分析，以研究血脂生物标志物（如总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C））在 ALI 对非酒精性脂肪肝和房颤患病率的影响中的作用：结果：在对潜在的混杂因素进行调整后，发现ALI与非酒精性脂肪肝和房颤患病率之间存在显著的正相关。与ALI三分层1的参与者相比，三分层3的参与者发生非酒精性脂肪肝的几率更高（几率比[OR]：3.16；95%置信区间[CI]：2.52-3.97），发生房颤的几率更高（几率比：3.17；95%置信区间[CI]：2.30-4.36）。三分层 2 和三分层 3 的参与者发生房颤的几率较低（趋势 P = 0.005）。此外，我们还发现 ALI 与非酒精性脂肪肝之间存在非线性关联。通过两段线性回归模型，我们发现非酒精性脂肪肝的拐点为 74.25。此外，总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）水平分别以 10.2% 和 4.2% 的比例介导了 ALI 与非酒精性脂肪肝之间的关系（均为 P 结论）：我们的研究结果表明，较高的 ALI 水平与非酒精性脂肪肝和房颤患病率的增加呈正相关，部分由血脂生物标志物介导。
期刊介绍：
Journal of Gastroenterology and Hepatology is produced 12 times per year and publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. Papers cover the medical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas. All submitted papers are reviewed by at least two referees expert in the field of the submitted paper.
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