Semen static oxidation-reduction potential is not helpful in evaluating male fertility.

IF 3.2 2区医学 Q1 ANDROLOGY

Andrology Pub Date : 2024-10-10 DOI:10.1111/andr.13759

Thiago Pardini Furtado, Vadim Osadchiy, Marcelo Horta Furtado

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引用次数: 0

Abstract

Background: Infertility affects a significant percentage of couples worldwide, with male infertility contributing substantially in a considerable number of cases. Research indicates that oxidative stress is a critical factor impacting male fertility.

Objective: To explore the relationship between semen static oxidation-reduction potential (sORP), sperm parameters, and validated biomarkers of oxidative stress in infertile men.

Materials and methods: This cross-sectional study involved 202 men diagnosed with idiopathic male factor infertility and male partners from couples with unexplained infertility. Multivariable linear regression to query the associations between sORP, sperm parameters, and oxidative aggression biomarkers (lipid peroxidation, mitochondrial membrane potential, annexin V, and sperm DNA fragmentation).

Results: SORP has no linear association with any semen analysis parameter. Furthermore, its relationship with validated biomarkers of oxidative stress was inconsistent. sORP was inversely related to lipid peroxidation (multivariable linear regression coefficient: -0.64), positively associated with sperm DNA fragmentation (multivariable linear regression coefficient: 3.20), and unrelated to mitochondrial membrane potential or annexin V.

Conclusions: There is no clear or consistent relationship between sORP and validated oxidative aggression biomarkers or sperm parameters. Our findings suggest that sORP is unlikely to be helpful in the evaluation of a male with idiopathic infertility.

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精液静态氧化还原电位无助于评估男性生育能力。

背景：不孕不育症影响着全球相当大比例的夫妇，其中男性不育症在相当多的病例中占很大比例。研究表明，氧化应激是影响男性生育能力的一个关键因素：探讨不育男性精液静态氧化还原电位（sORP）、精子参数和氧化应激的有效生物标志物之间的关系：这项横断面研究涉及 202 名被诊断为特发性男性因素不育的男性和不明原因不育夫妇的男性伴侣。结果：SORP与精子参数和氧化侵袭生物标志物（脂质过氧化、线粒体膜电位、附件素V和精子DNA碎片）之间没有线性关系：结果：SORP 与任何精液分析参数都没有线性关系。此外，SORP 与氧化应激的有效生物标志物的关系也不一致。SORP 与脂质过氧化成反比（多变量线性回归系数：-0.64），与精子 DNA 断裂成正比（多变量线性回归系数：3.20），与线粒体膜电位或附件素 V 无关：结论：sORP 与有效的氧化侵害生物标志物或精子参数之间没有明确或一致的关系。我们的研究结果表明，sORP 不太可能有助于评估男性特发性不育症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Andrology ANDROLOGY-

CiteScore

9.10

自引率

6.70%

发文量

200

期刊介绍： Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology