The rejection that defies antirejection drugs—chronic vascular rejection (allograft vasculopathy): The role of terminology and linguistic relativity

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-10-09 DOI:10.1016/j.drudis.2024.104202

Vladimir M. Subbotin , Michael V. Subotin

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引用次数: 0

Abstract

While allograft loss due to acute rejection has been dramatically reduced due to the introduction of immunophilins, this therapy has little effect on allografts lost due to chronic vascular rejection. This situation may be due to a misnomer of the pathology. Specifically, its designation as ‘chronic rejection’ has given the wrong impression that the cause of the disease has been identified. Analyzing this phenomenon under the rubric of linguistic relativity suggests that the words chosen to name the disease may have restricted our cognitive ability to solve the problem. Thus, we have to step out of the ‘alloimmunity/rejection box’.

Let’s pause between our words,

Speak and fall silent again,

So that the meaning of the word just spoken,

Sounds a clearer echo in our heads.

Let’s pause between our words.

Andrey Makarevich.

查看原文本刊更多论文

对抗抗排斥药物的排斥反应--慢性血管排斥反应（异体移植物血管病变）：术语和语言相对性的作用。

由于引入了免疫亲和素，急性排斥反应导致的同种异体移植物损失已大大减少，但这种疗法对慢性血管排斥反应导致的同种异体移植物损失却收效甚微。造成这种情况的原因可能是病理名称的错误。具体来说，将其命名为 "慢性排斥反应 "给人一种错误的印象，以为已经找到了病因。从语言相对性的角度来分析这一现象，我们就会发现，命名这一疾病的词语可能限制了我们解决问题的认知能力。因此，我们必须跳出 "异体免疫/排斥 "的框框。让我们在说话之间停顿一下，说过之后再沉默，这样，刚刚说过的那个词的意思就会在我们的脑海中响起更清晰的回声。让我们停顿一下安德烈-马卡列维奇

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.