Black Phosphorus Nanosheets-Loaded Mussel-Inspired Hydrogel with Wet Adhesion, Photothermal Antimicrobial, and In Situ Remineralization Capabilities for Caries Prevention.
Ying Ran, Jiayi Shi, Yiqin Ding, Lujian Li, Dandan Lu, Youyun Zeng, Dongchao Qiu, Jie Yu, Xiaojun Cai, Yihuai Pan
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引用次数: 0
Abstract
The main features of early caries are the massive colonization of cariogenic bacteria and demineralization of tooth enamel by the acids that they produce. Owing to the lack of effective treatments, the development of anticaries therapeutics with both antimicrobial and remineralizing properties is urgently required. Black phosphorus nanosheets (BPNs) are ideal therapeutics for the treatment of early caries because they can mediate photothermal antibacterial activity and subsequently promote remineralization by generating PO43-. However, the dynamic and wet environment of the oral cavity prevents the long-term adhesion of BPNs to the tooth surface. In this study, using catechol-modified chitosan and PLGA-PEG-PLGA as raw materials, a mussel-inspired versatile hydrogel, BP@CP5, is presented that can be used to physically load BPNs. BP@CP5 has exceptional injectability and can firmly adhere to tooth surfaces for up to 24 h. Upon irradiation, BP@CP5 can quickly eliminate ≈99% of Streptococcus mutans and Streptococcus sanguinis; furthermore, the PO43- generated via degradation also promotes rapid remineralization of enamel slabs. Importantly, the vivo rodent caries modeling results further confirm the excellent caries-prevention properties of BP@CP5. This study demonstrates that BP@CP5 is a promising anticaries material for caries management.
期刊介绍:
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.