Significance of negative cervical cytology and positive HPV in the diagnosis of cervical lesions by colposcopy.

IF 1.7 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Open Medicine Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI:10.1515/med-2024-1051
Changhong Zhang, Liu Dong, Kejie Liu, Hong Xiao, Hao Si, Xiaoqin Wang, Hui Wang
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引用次数: 0

Abstract

Objective: The aim of this study was to investigate the significance of colposcopy in diagnosing cervical lesions when negative cervical cytology is combined with positive human papillomavirus (HPV).

Methods: Overall, 370 patients with cervical epithelial lesions who had negative cervical fluid-based cytology combined with positive HPV results were selected and analysed for severity of cervical lesions and HPV distribution.

Results: Among the patients with cervical lesions, 242 had a single HPV infection, and 128 cases had multiple infections. No significant difference was found between HPV single infection and multiple infections in both groups of patients with cervical lesions (P > 0.05). Furthermore, 137 had non-HPV 16 and 18, accounting for 37.30% of all the patients with cervical lesions. Among them, HPV 52, 58, and 33 infections were the most common at 38.69, 30.66 and 29.20%, respectively - significantly higher than other high-risk HPV types (P < 0.05).

Conclusion: High-risk HPV testing is crucial in patients with negative cervical fluid-based cytology combined with positive HPV results. Patients with HPV 16 and 18 and those with simple HPV 52, 58, and 33 infections should undergo timely colposcopy.

阴道镜检查诊断宫颈病变时宫颈细胞学阴性和 HPV 阳性的意义。
研究目的本研究旨在探讨当宫颈细胞学阴性合并人乳头瘤病毒(HPV)阳性时,阴道镜在诊断宫颈病变中的意义:方法:选取宫颈液基细胞学检查阴性合并HPV阳性的370例宫颈上皮病变患者,分析其宫颈病变的严重程度和HPV的分布情况:结果:在宫颈病变患者中,242 例为单个 HPV 感染,128 例为多个感染。在两组宫颈病变患者中,HPV 单一感染与多重感染无明显差异(P>0.05)。此外,137 例宫颈病变患者感染了非 HPV16 和 18,占所有宫颈病变患者的 37.30%。其中,HPV 52、58 和 33 感染最为常见,分别占 38.69%、30.66% 和 29.20%,明显高于其他高危 HPV 类型(P < 0.05):高危 HPV 检测对于宫颈液基细胞学检查阴性而 HPV 结果阳性的患者至关重要。HPV16和18型患者以及单纯HPV52、58和33型感染者应及时接受阴道镜检查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Open Medicine
Open Medicine Medicine-General Medicine
CiteScore
3.00
自引率
0.00%
发文量
153
审稿时长
20 weeks
期刊介绍: Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.
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