Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative review.

Singapore medical journal Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI:10.4103/singaporemedj.SMJ-2024-133
Xiao Wei Tan, Hasvinjit Kaur Gulwant Singh, Jovi Zheng Jie Koh, Rachel Si Yun Tan, Phern Chern Tor
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Abstract

Abstract: Transcranial magnetic stimulation (TMS) is a promising intervention for treatment-resistant psychiatric disorders. However, conventional TMS typically utilises a one-size-fits-all approach when determining stimulation targets. Recent retrospective brain circuit-based analyses using lesion network mapping have suggested that a left dorsal lateral prefrontal cortex target has a higher efficacy for alleviating depression symptoms, a dorsomedial prefrontal cortex target is more effective for anxiety symptoms, and a rostromedial prefrontal cortex target is effective for schizophrenia-associated psychiatric symptoms. Nonetheless, symptom-specific brain circuit targeting has not been tested prospectively. We conducted a narrative review of selected literature to investigate individualised targeting for TMS and discuss potential future directions to elucidate the efficacy of this approach.

个性化经颅磁刺激治疗耐药抑郁症、合并焦虑的抑郁症和精神分裂症阴性症状:综述。
摘要:经颅磁刺激(TMS)是一种很有前景的治疗耐药性精神障碍的干预方法。然而,传统的经颅磁刺激在确定刺激目标时通常采用一刀切的方法。最近利用病变网络图进行的基于脑回路的回顾性分析表明,左侧背外侧前额叶皮层靶点对缓解抑郁症状更有效,背内侧前额叶皮层靶点对焦虑症状更有效,而喙内侧前额叶皮层靶点对精神分裂症相关精神症状有效。然而,针对特定症状的脑回路靶向治疗尚未经过前瞻性测试。我们对部分文献进行了叙述性综述,研究了TMS的个体化靶向治疗,并讨论了阐明这种方法疗效的潜在未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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