Efficacité de 6 scénarios de décontamination de bras de fauteuils contaminés volontairement au cyclophosphamide.

The Canadian journal of hospital pharmacy Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI:10.4212/cjhp.3588

Mathilde Dupré, Manon Marc, Jean-François Bussières

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Abstract

Background: The arms of chairs in outpatient oncology clinics are frequently contaminated with cyclophosphamide.

Objective: To evaluate the effectiveness of decontamination scenarios.

Methods: This was a descriptive simulation-type study of 6 decontamination scenarios of a silicone fabric surface contaminated with 10 μg of cyclophosphamide. The decontamination products tested (quaternary ammonium, 0.5% hydrogen peroxide, 0.005% detergent, and sodium hypochlorite 0.5%) were applied with microfibre wipes. Residual contamination was measured using an ultra-performance liquid chromatography-tandem mass spectrometry system with identical cyclophosphamide detection and quantification limits (0.0006 ng/cm²).

Results: Among the 59 samples, 3 blanks were negative, 5 allowed measurement of the recovery rate (93.7% [standard deviation 4.6%]), and 51 were experimental. The average efficiency of the agents was greater than or equal to 99.79%. Regardless of the agent used, effectiveness was 99.30% (SD 1.20%) after 1 cleanse (n = 18), 99.90% (SD 0.15%) after 2 cleanses (n = 18), and 99.95% (SD 0.06%) after 3 cleanses (n = 15).

Conclusion: The 6 decontamination scenarios were effective. Repeated cleaning marginally increased the effectiveness of decontamination.

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对故意沾染环磷酰胺的椅子扶手进行净化的 6 种方案的有效性。

背景：肿瘤门诊椅子的扶手经常被环磷酰胺污染：肿瘤门诊的椅子扶手经常受到环磷酰胺的污染：评估净化方案的有效性：这是一项描述性模拟研究，针对硅胶织物表面被 10 μg 环磷酰胺污染的 6 个去污方案进行了研究。使用微纤维抹布擦拭测试的去污产品（季铵盐、0.5% 过氧化氢、0.005% 洗涤剂和 0.5% 次氯酸钠）。使用超高效液相色谱-串联质谱系统测量残留污染，环磷酰胺的检测和定量限（0.0006 ng/cm2）完全相同：在 59 份样本中，3 份空白样本为阴性，5 份样本可测量回收率（93.7% [标准偏差 4.6%]），51 份样本为实验样本。药剂的平均效率大于或等于 99.79%。无论使用哪种药剂，经过 1 次清洗（n = 18）后的有效率为 99.30%（标准差为 1.20%），经过 2 次清洗（n = 18）后的有效率为 99.90%（标准差为 0.15%），经过 3 次清洗（n = 15）后的有效率为 99.95%（标准差为 0.06%）：结论：6 种净化方案均有效。结论：6 种净化方案均有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Canadian journal of hospital pharmacy

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