Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Pub Date : 2024-10-01 DOI:10.19852/j.cnki.jtcm.20240828.008

X U Yingshan, W U Chunxiao, Y U Wei, Guo Hongji, L U Liming, X U Nenggui, Tang Chunzhi

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Abstract

Objective: To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.

Methods: We searched for all relevant trials published through Oct 7, 2022 from seven databases. Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool. A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.

Results: A total of 101 studies involving 2148 animals were included. For most studies, primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat's postsynaptic density thickness [Standardized Mean Difference (SMD) = 1.41, 95% confidence interval (CI) (0.59, 2.23), P = 0.0008], numerical density of synapses [SMD = 1.55, 95% CI (0.48, 2.63), P = 0.005] compared with non-EA-treated. Similarly, EA could improve parts of biomarkers of synapses, neurogenesis, angiogenesis and neurotrophin activity than the control group (P < 0.05).

Conclusion: The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity. More rigorous and high quality studies should be conducted in the future.

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实验性缺血性中风中电针相关脑可塑性的系统回顾和元分析。

目的：系统评估电针在缺血性中风引起的脑损伤中维持脑可塑性的作用：系统评估电针在缺血性中风介导的脑损伤中维持脑可塑性的作用：我们从七个数据库中检索了截至 2022 年 10 月 7 日发表的所有相关试验。使用 CAMARADES 偏倚风险工具评估方法学质量。使用Review Manager v.5.3软件对比较效应进行了元分析：共纳入 101 项研究，涉及 2148 只动物。对于大多数研究，Meta 分析的主要结果显示，与非 EA 治疗相比，EA 能显著改善缺血性中风大鼠突触后密度厚度[标准化平均差（SMD）= 1.41，95% 置信区间（CI）（0.59，2.23），P = 0.0008]、突触数值密度[SMD = 1.55，95% CI（0.48，2.63），P = 0.005]。同样，与对照组相比，EA能改善突触、神经发生、血管生成和神经营养素活性等生物标志物的部分指标（P 0.05）：现有证据表明，EA 可通过大脑可塑性调节缺血性中风。结论：现有证据表明，EA 可通过脑可塑性调节缺血性中风，未来应开展更严格、更高质量的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

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