Association of multiple urinary metals/metalloids with obesity defined by body fat percentage: A cross-sectional study among Guangxi Zhuang ethnic in China

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2024-09-28 DOI:10.1016/j.jtemb.2024.127538

Fangfang Lv , Lidi Lei , Gangjie Wei , Qunjiao Jiang , Caimei Mo , Jinxiu Li , Peini Lu , Xuemei Xu , Xuanqian Huang , Dongping Huang , Li Su , Xiaoqiang Qiu , Xiaoyun Zeng , Shun Liu

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引用次数: 0

Abstract

Background

Previous studies confirmed a link between urinary metals/metalloids and obesity; however, the majority of these studies defined obesity using body mass index (BMI) or waist circumference (WC), and their results were not constantly consistent. Studies defining obesity based on body fat percentage (BFP) is less reported.

Methods

A total of 5405 participants aged 35–74 from Guangxi Zhuang ethnic group in China were included in the analysis. Inductively coupled plasma mass spectrometry (ICP-MS) was used to detect the concentrations of 22 metals/metalloids in urine. Using a binary logistic regression model, the impact of individual metal/metalloid on the risk of BFP/obesity was analyzed, and the LASSO regression model was employed to choose metals/metalloids independently related with BFP/obesity to construct a multiple-metal models. The quantile g-computation model was used to evaluate the combined impacts of metals/metalloids on BFP/obesity.

Results

In multiple-metal models, compared with the lowest quartile, the highest quartile of urinary concentrations of Mg, Cd, and Ti was significantly associated with a reduced risk of BFP/obesity (Mg: OR=0.66, 95 %CI: 0.51, 0.85; Cd: OR=0.63, 95 %CI: 0.49, 0.82; Ti: OR=0.73, 95 %CI: 0.57, 0.93). Conversely, the highest quartiles of urinary concentrations of Zn, V, and Sb was significantly associated with an increased risk of BFP/obesity (Zn: OR=1.75, 95 %CI: 1.39, 2.22; V: OR=1.63, 95 %CI: 1.25, 2.14; Sb: OR=1.38, 95 %CI: 1.06, 1.79). In quantile g-computation analysis, Mg, Cd, and Sn were the main contributors to negative effects, while Zn, V, and Sb were the main contributors to positive effect, although no significant relationship was observed between the multiple metal/metalloid mixtures and BFP/obesity.

Conclusions

According to our study, urinary Mg, Cd, and Ti levels were negatively associated with BFP/obesity risk, and Zn, V, and Sb levels were positively associated with BFP/obesity risk. However, these associations need to be further verified by longitudinal studies, and the molecular mechanisms need to be further explored by animal and cell experiments.

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尿液中多种金属/类金属与以体脂率定义的肥胖的关系：中国广西壮族横断面研究。

背景：以往的研究证实，尿液中的金属/类金属与肥胖之间存在联系；但是，这些研究大多使用体重指数（BMI）或腰围（WC）来定义肥胖，而且结果并不一致。根据体脂率（BFP）定义肥胖的研究报道较少：方法：共纳入 5405 名来自中国广西壮族的 35-74 岁参与者进行分析。采用电感耦合等离子体质谱法（ICP-MS）检测尿液中 22 种金属/类金属的浓度。利用二元逻辑回归模型分析了单个金属/类金属对BFP/肥胖风险的影响，并采用LASSO回归模型选择与BFP/肥胖独立相关的金属/类金属构建多金属模型。结果表明，在多金属模型中，金属/类金属与 BFP/肥胖的相关性与 BFP/肥胖的相关性相比较，金属/类金属与 BFP/肥胖的相关性与 BFP/肥胖的相关性相比较低：结果：在多金属模型中，与最低四分位数相比，尿液中镁、镉和钛浓度的最高四分位数与 BFP/肥胖风险的降低有显著相关性（镁：OR=0.66，95%CI=0.01，95%CI=0.01）：OR=0.66，95 %CI：0.51，0.85；Cd：OR=0.63，95%CI：0.49，0.82；Ti：OR=0.73，95%CI：0.57，0.93）。相反，尿液中 Zn、V 和 Sb 浓度的最高四分位数与 BFP/肥胖风险的增加有显著相关性（Zn：OR=1.75，95 %CI：1.39，2.22；V：OR=1.63，95 %CI：1.25，2.14；Sb：OR=1.38，95%CI：1.06，1.79）。在量子 g 计算分析中，Mg、Cd 和 Sn 是产生负面影响的主要因素，而 Zn、V 和 Sb 则是产生正面影响的主要因素，但在多种金属/类金属混合物与 BFP/肥胖之间未观察到显著关系：结论：根据我们的研究，尿液中的镁、镉和钛水平与BFP/肥胖风险呈负相关，而锌、钒和锑水平与BFP/肥胖风险呈正相关。然而，这些关联还需要通过纵向研究来进一步验证，其分子机制也需要通过动物和细胞实验来进一步探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.