Microproteins in cancer: identification, biological functions, and clinical implications.

IF 13.6 2区 生物学 Q1 GENETICS & HEREDITY
Damon A Hofman, John R Prensner, Sebastiaan van Heesch
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引用次数: 0

Abstract

Cancer continues to be a major global health challenge, accounting for 10 million deaths annually worldwide. Since the inception of genome-wide cancer sequencing studies 20 years ago, a core set of ~700 oncogenes and tumor suppressor genes has become the basis for cancer research. However, this research has been based largely on an understanding that the human genome encodes ~19 500 protein-coding genes. Complementing this genomic landscape, recent advances have described numerous microproteins which are now poised to redefine our understanding of oncogenic processes and open new avenues for therapeutic intervention. This review explores the emerging evidence for microprotein involvement in cancer mechanisms and discusses potential therapeutic applications, with an emphasis on highlighting recent advances in the field.

癌症中的微蛋白:识别、生物功能和临床意义。
癌症仍然是全球健康的一大挑战,每年全球有 1000 万人死于癌症。自 20 年前开始进行全基因组癌症测序研究以来,一组约 700 个致癌基因和抑癌基因的核心基因已成为癌症研究的基础。然而,这种研究主要是基于对人类基因组编码约 19 500 个蛋白编码基因的了解。作为对这一基因组图谱的补充,最近的研究进展描述了许多微蛋白,这些微蛋白现在有望重新定义我们对致癌过程的理解,并为治疗干预开辟新的途径。这篇综述探讨了微蛋白参与癌症机制的新证据,并讨论了潜在的治疗应用,重点强调了该领域的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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