Global burden of viral infectious diseases of poverty based on Global Burden of Diseases Study 2021.

IF 8.1 1区 医学
Xin-Chen Li, Yan-Yan Zhang, Qi-Yu Zhang, Jing-Shu Liu, Jin-Jun Ran, Le-Fei Han, Xiao-Xi Zhang
{"title":"Global burden of viral infectious diseases of poverty based on Global Burden of Diseases Study 2021.","authors":"Xin-Chen Li, Yan-Yan Zhang, Qi-Yu Zhang, Jing-Shu Liu, Jin-Jun Ran, Le-Fei Han, Xiao-Xi Zhang","doi":"10.1186/s40249-024-01234-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Viral infectious diseases of poverty (vIDPs) remain a significant global health challenge. Despite their profound impact, the burden of these diseases is not comprehensively quantified. This study aims to analyze the global burden of six major vIDPs, including coronavirus disease 2019 (COVID-19), HIV/AIDS, acute hepatitis, dengue, rabies, and Ebola virus disease (EVD), using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021).</p><p><strong>Methods: </strong>Following the GBD 2021 framework, we analyzed the incidence, mortality, and disability-adjusted life years (DALYs) of the six vIDPs across 204 countries and territories from 1990 to 2021. We examined the association between the Socio-Demographic Index (SDI) and the burden of vIDPs. All estimates were reported as numbers and rates per 100,000 population, calculated using the Bayesian statistical model employed by GBD 2021, with 95% uncertainty intervals (UI).</p><p><strong>Results: </strong>In 2021, vIDPs caused approximately 8.7 million deaths and 259.2 million DALYs, accounting for 12.8% and 9.0% of the global all-cause totals, respectively. Globally, the burden of vIDPs varied significantly: COVID-19 caused around 7.9 million (95% UI: 7.5, 8.4) deaths and 212.0 million (95% UI 197.9, 234.7) DALYs in 2021. Acute hepatitis had the second-highest age-standardized incidence rate, with 3411.5 (95% UI: 3201.8, 3631.3) per 100,000 population, while HIV/AIDS had a high age-standardized prevalence rate, with 483.1 (95% UI: 459.0, 511.4) per 100,000 population. Dengue incidence cases rose from 26.5 million (95% UI: 3.9, 51.9) in 1990 to 59.0 million (95% UI: 15.5, 106.9) in 2021. Rabies, although reduced in prevalence, continued to pose a significant mortality risk. EVD had the lowest overall burden but significant outbreak impacts. Age-standardized DALY rates for vIDPs were significantly negatively correlated with SDI: acute hepatitis (r = -0.8, P < 0.0001), rabies (r = -0.7, P < 0.0001), HIV/AIDS (r = -0.6, P < 0.0001), COVID-19 (r = -0.5, P < 0.0001), dengue (r = -0.4, P < 0.0001), and EVD (r = -0.2, P < 0.005).</p><p><strong>Conclusions: </strong>VIDPs pose major public health challenges worldwide, with significant regional, age, and gender disparities. The results underscore the need for targeted interventions and international cooperation to mitigate the burden of these diseases. Policymakers can use these findings to implement cost-effective interventions and improve health outcomes, particularly in regions with high or increasing burdens.</p>","PeriodicalId":48820,"journal":{"name":"Infectious Diseases of Poverty","volume":"13 1","pages":"71"},"PeriodicalIF":8.1000,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459951/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious Diseases of Poverty","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40249-024-01234-z","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Viral infectious diseases of poverty (vIDPs) remain a significant global health challenge. Despite their profound impact, the burden of these diseases is not comprehensively quantified. This study aims to analyze the global burden of six major vIDPs, including coronavirus disease 2019 (COVID-19), HIV/AIDS, acute hepatitis, dengue, rabies, and Ebola virus disease (EVD), using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021).

Methods: Following the GBD 2021 framework, we analyzed the incidence, mortality, and disability-adjusted life years (DALYs) of the six vIDPs across 204 countries and territories from 1990 to 2021. We examined the association between the Socio-Demographic Index (SDI) and the burden of vIDPs. All estimates were reported as numbers and rates per 100,000 population, calculated using the Bayesian statistical model employed by GBD 2021, with 95% uncertainty intervals (UI).

Results: In 2021, vIDPs caused approximately 8.7 million deaths and 259.2 million DALYs, accounting for 12.8% and 9.0% of the global all-cause totals, respectively. Globally, the burden of vIDPs varied significantly: COVID-19 caused around 7.9 million (95% UI: 7.5, 8.4) deaths and 212.0 million (95% UI 197.9, 234.7) DALYs in 2021. Acute hepatitis had the second-highest age-standardized incidence rate, with 3411.5 (95% UI: 3201.8, 3631.3) per 100,000 population, while HIV/AIDS had a high age-standardized prevalence rate, with 483.1 (95% UI: 459.0, 511.4) per 100,000 population. Dengue incidence cases rose from 26.5 million (95% UI: 3.9, 51.9) in 1990 to 59.0 million (95% UI: 15.5, 106.9) in 2021. Rabies, although reduced in prevalence, continued to pose a significant mortality risk. EVD had the lowest overall burden but significant outbreak impacts. Age-standardized DALY rates for vIDPs were significantly negatively correlated with SDI: acute hepatitis (r = -0.8, P < 0.0001), rabies (r = -0.7, P < 0.0001), HIV/AIDS (r = -0.6, P < 0.0001), COVID-19 (r = -0.5, P < 0.0001), dengue (r = -0.4, P < 0.0001), and EVD (r = -0.2, P < 0.005).

Conclusions: VIDPs pose major public health challenges worldwide, with significant regional, age, and gender disparities. The results underscore the need for targeted interventions and international cooperation to mitigate the burden of these diseases. Policymakers can use these findings to implement cost-effective interventions and improve health outcomes, particularly in regions with high or increasing burdens.

根据《2021 年全球疾病负担研究》得出的全球贫困病毒性传染病负担。
背景:贫困病毒性传染病(vIDPs)仍然是全球健康面临的重大挑战。尽管这些疾病影响深远,但其造成的负担并未得到全面量化。本研究旨在利用《2021 年全球疾病负担、伤害和风险因素研究》(GBD 2021)的数据,分析六种主要病毒性传染病的全球负担,包括 2019 年冠状病毒病(COVID-19)、艾滋病毒/艾滋病、急性肝炎、登革热、狂犬病和埃博拉病毒病(EVD):按照 GBD 2021 框架,我们分析了 1990 年至 2021 年期间 204 个国家和地区的六种病毒性传染病的发病率、死亡率和残疾调整生命年(DALYs)。我们研究了社会人口指数(SDI)与病毒性腹泻病负担之间的关联。所有估计值均以每十万人中的数字和比率为单位进行报告,并采用《2021年全球生物多样性数据》所使用的贝叶斯统计模型进行计算,以及95%的不确定性区间(UI):结果:2021 年,血管内皮生长因子病造成约 870 万人死亡和 2.592 亿人残疾调整寿命年数,分别占全球全因总数的 12.8% 和 9.0%。在全球范围内,病毒性腹泻病造成的负担差异很大:2021 年,COVID-19 造成约 790 万人死亡(95% UI:750,840),2.12 亿人残疾调整寿命年数(95% UI:1.979,234.7)。急性肝炎的年龄标准化发病率位居第二,为每 10 万人 3411.5 例(95% UI:3201.8,3631.3),而艾滋病毒/艾滋病的年龄标准化流行率较高,为每 10 万人 483.1 例(95% UI:459.0,511.4)。登革热发病率从 1990 年的 2650 万例(95% UI:390,51.9)上升到 2021 年的 5900 万例(95% UI:1550,106.9)。狂犬病虽然发病率有所下降,但仍有很大的死亡风险。EVD 的总体负担最低,但对疫情爆发有重大影响。病毒性传染病的年龄标准化残疾调整寿命年率与 SDI:急性肝炎呈显著负相关(r = -0.8,P 结论:病毒性传染病对公共卫生构成重大威胁:病毒性肝炎在全球范围内构成了重大的公共卫生挑战,并存在明显的地区、年龄和性别差异。研究结果表明,有必要采取有针对性的干预措施并开展国际合作,以减轻这些疾病造成的负担。政策制定者可以利用这些研究结果来实施具有成本效益的干预措施并改善健康结果,尤其是在负担较重或负担不断加重的地区。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Infectious Diseases of Poverty
Infectious Diseases of Poverty INFECTIOUS DISEASES-
自引率
1.20%
发文量
368
期刊介绍: Infectious Diseases of Poverty is an open access, peer-reviewed journal that focuses on addressing essential public health questions related to infectious diseases of poverty. The journal covers a wide range of topics including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies and application. It also considers the transdisciplinary or multisectoral effects on health systems, ecohealth, environmental management, and innovative technology. The journal aims to identify and assess research and information gaps that hinder progress towards new interventions for public health problems in the developing world. Additionally, it provides a platform for discussing these issues to advance research and evidence building for improved public health interventions in poor settings.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信