Coverage of community-wide mass drug administration platforms for soil-transmitted helminths in Benin, India, and Malawi: findings from the DeWorm3 project.

IF 8.1 1区 医学
Arianna Rubin Means, Kristjana Hrönn Ásbjörnsdóttir, Katherine C Sharrock, Sean R Galagan, Kumudha Aruldas, Euripide Avokpaho, Félicien Chabi, Katherine E Halliday, Parfait Houngbegnon, Gideon John Israel, Saravanakumar Puthupalayam Kaliappan, David Kennedy, Hugo Legge, William E Oswald, Gokila Palanisamy, Elliott Rogers, Joseph Timothy, Emily Pearman, Rohan Michael Ramesh, James Simwanza, Jasmine Farzana Sheik-Abdullah, Mariyam Sheikh, Comlanvi Innocent Togbevi, Stefan Witek-McManus, Rachel L Pullan, Robin Bailey, Khumbo Kalua, Moudachirou Ibikounlé, Adrian J F Luty, Sitara S R Ajjampur, Judd L Walson
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引用次数: 0

Abstract

Background: Soil-transmitted helminths (STH) affect approximately 1.5 billion people globally. The current STH control strategy is annual or twice-annual preventive chemotherapy, typically school-based deworming targeting children and women of reproductive age. Mathematical modeling suggests that it may be possible to interrupt STH transmission through high-coverage community-wide mass drug administration (cMDA). DeWorm3 is a cluster randomized trial testing cMDA for prevalence reduction and transmission interruption. The purpose of this study is to describe coverage of cMDA in study clusters over time and correlates of coverage at individual and cluster levels.

Methods: From 2018-2020, DeWorm3 delivered six rounds of cMDA with 400 mg albendazole at sites in Benin, India, and Malawi. We report coverage, treatment uptake, and directly observed therapy across all rounds. Factors associated with coverage at the cluster level were identified using binomial generalized estimating equations, while factors associated with non-treatment at the individual level were identified using binomial mixed-effects models.

Results: Coverage was high across all clusters and rounds, exceeding the WHO target of 75% in all sites and across all rounds (78% to 95%); cluster-level coverage tended to increase over time. Younger, unmarried, and migratory adults were more likely to be untreated at all sites; adult males were more likely to be untreated in Benin and Malawi. Among children, girls were more likely to be untreated, as were non-school-attending and migratory children. Higher adult education was associated with greater odds of non-treatment among adults, but lower odds among children in the household. Belonging to a less wealthy or minority language-speaking household was associated with non-treatment among both adults and children.

Conclusions: It is possible to deliver community-wide MDA with high coverage. Unique individual and community-level factors influence treatment across settings, and these may be addressed through targeted programming.

Trial registration: Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH), NCT03014167.

贝宁、印度和马拉维全社区土壤传播蠕虫大规模用药平台的覆盖范围:DeWorm3 项目的发现。
背景:全球约有 15 亿人受到土壤传播蠕虫(STH)的影响。目前的 STH 控制策略是每年一次或两次的预防性化疗,通常是针对儿童和育龄妇女的校内驱虫。数学模型表明,通过高覆盖率的全社区大规模用药(cMDA)有可能阻断性传播感染。DeWorm3 是一项分组随机试验,测试 cMDA 如何降低流行率和阻断传播。本研究的目的是描述随着时间推移,cMDA 在研究群组中的覆盖率,以及个人和群组层面覆盖率的相关因素:从 2018-2020 年,DeWorm3 在贝宁、印度和马拉维的研究地点提供了六轮使用 400 毫克阿苯达唑的 cMDA。我们报告了所有轮次的覆盖率、治疗吸收率和直接观察疗法。使用二项式广义估计方程确定了群组水平上与覆盖率相关的因素,而使用二项式混合效应模型确定了个体水平上与未治疗相关的因素:所有群组和所有轮次的覆盖率都很高,在所有地点和所有轮次都超过了世界卫生组织规定的 75% 的目标(78% 至 95%);随着时间的推移,群组层面的覆盖率呈上升趋势。在所有地点,年轻、未婚和移徙的成年人更有可能未接受治疗;在贝宁和马拉维,成年男性更有可能未接受治疗。在儿童中,女孩更有可能未接受治疗,非在校儿童和移民儿童也是如此。成人受教育程度越高,成人未接受治疗的几率越大,但家中儿童未接受治疗的几率较低。属于不太富裕或讲少数民族语言的家庭与成人和儿童未接受治疗有关:结论:在社区范围内提供高覆盖率的 MDA 是可行的。结论:在社区范围内提供高覆盖率的 MDA 是可能的。个人和社区层面的独特因素会影响不同环境下的治疗,这些因素可以通过有针对性的计划来解决:试验注册:阻断土壤传播蠕虫(STH)传播的可行性实地研究,NCT03014167。
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来源期刊
Infectious Diseases of Poverty
Infectious Diseases of Poverty INFECTIOUS DISEASES-
自引率
1.20%
发文量
368
期刊介绍: Infectious Diseases of Poverty is an open access, peer-reviewed journal that focuses on addressing essential public health questions related to infectious diseases of poverty. The journal covers a wide range of topics including the biology of pathogens and vectors, diagnosis and detection, treatment and case management, epidemiology and modeling, zoonotic hosts and animal reservoirs, control strategies and implementation, new technologies and application. It also considers the transdisciplinary or multisectoral effects on health systems, ecohealth, environmental management, and innovative technology. The journal aims to identify and assess research and information gaps that hinder progress towards new interventions for public health problems in the developing world. Additionally, it provides a platform for discussing these issues to advance research and evidence building for improved public health interventions in poor settings.
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