Novel Index Combining Pan-Immune-Inflammatory Index and Hemoglobin Levels (PIV/Hb) Predicts Trismus Rates Efficiently after Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer.

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI:10.1155/2024/2124006
Efsun Somay, Busra Yilmaz, Erkan Topkan, Beyza Sirin Ozdemir, Duriye Ozturk, Ali Ayberk Besen, Huseyin Mertsoylu, Ugur Selek
{"title":"Novel Index Combining Pan-Immune-Inflammatory Index and Hemoglobin Levels (PIV/Hb) Predicts Trismus Rates Efficiently after Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer.","authors":"Efsun Somay, Busra Yilmaz, Erkan Topkan, Beyza Sirin Ozdemir, Duriye Ozturk, Ali Ayberk Besen, Huseyin Mertsoylu, Ugur Selek","doi":"10.1155/2024/2124006","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the predictive potency of a novel index combining the pan-immune-inflammatory index and hemoglobin levels (PIV/Hb) for the prevalence of radiation-induced trismus (RIT) in patients with locally advanced nasopharyngeal cancer (LA-NPC) receiving concurrent chemoradiotherapy (CCRT).</p><p><strong>Methods: </strong>Data from 228 LA-NPC patients were retrospectively examined. Maximum mouth openings (MMO) were measured to confirm the presence of RIT, defined as MMOs ≤35 mm. Complete blood test results from the first day of CCRT were used to calculate PIV/Hb levels. A potential relationship between pretreatment PIV/Hb and the RIT status was evaluated using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Post-CCRT RIT was diagnosed in 20.2% of the patients. The ROC curve analysis determined 68.4 g/dL as the ideal PIV/Hb cutoff that effectively divided patients into two distinct groups (area under the curve: 94.7%; specificity: 86.4%; sensitivity: 87.4%). RIT was significantly more prevalent in the PIV/Hb > 68 group than in the PIV/Hb < 68 group (58.8% vs. 3.8%; <i>P</i> < 0.001). Multivariate logistic regression analysis showed that a pre-CCRT PIV > 68 was independently associated with significantly higher rates of RIT.</p><p><strong>Conclusion: </strong>Higher pretreatment levels of the novel PIV/Hb index predict increased RIT rates following definitive CCRT for LA-NPCs.</p>","PeriodicalId":45960,"journal":{"name":"International Journal of Surgical Oncology","volume":"2024 ","pages":"2124006"},"PeriodicalIF":1.6000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458266/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Surgical Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2024/2124006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: To evaluate the predictive potency of a novel index combining the pan-immune-inflammatory index and hemoglobin levels (PIV/Hb) for the prevalence of radiation-induced trismus (RIT) in patients with locally advanced nasopharyngeal cancer (LA-NPC) receiving concurrent chemoradiotherapy (CCRT).

Methods: Data from 228 LA-NPC patients were retrospectively examined. Maximum mouth openings (MMO) were measured to confirm the presence of RIT, defined as MMOs ≤35 mm. Complete blood test results from the first day of CCRT were used to calculate PIV/Hb levels. A potential relationship between pretreatment PIV/Hb and the RIT status was evaluated using receiver operating characteristic (ROC) curve analysis.

Results: Post-CCRT RIT was diagnosed in 20.2% of the patients. The ROC curve analysis determined 68.4 g/dL as the ideal PIV/Hb cutoff that effectively divided patients into two distinct groups (area under the curve: 94.7%; specificity: 86.4%; sensitivity: 87.4%). RIT was significantly more prevalent in the PIV/Hb > 68 group than in the PIV/Hb < 68 group (58.8% vs. 3.8%; P < 0.001). Multivariate logistic regression analysis showed that a pre-CCRT PIV > 68 was independently associated with significantly higher rates of RIT.

Conclusion: Higher pretreatment levels of the novel PIV/Hb index predict increased RIT rates following definitive CCRT for LA-NPCs.

结合泛免疫炎症指数和血红蛋白水平(PIV/Hb)的新指数能有效预测局部晚期鼻咽癌化疗后的三联征发生率
目的:评估结合泛免疫炎症指数和血红蛋白水平(PIV/Hb)的新型指数对同时接受化学放疗(CCRT)的局部晚期鼻咽癌(LA-NPC)患者放射诱发三联征(RIT)发生率的预测效力:方法: 对 228 名 LA-NPC 患者的数据进行了回顾性研究。测量最大张口度(MMO)以确认是否存在 RIT,MMO ≤35 mm 即为 RIT。CCRT 第一天的全血检验结果用于计算 PIV/Hb 水平。使用接收器操作特征(ROC)曲线分析评估了治疗前 PIV/Hb 与 RIT 状态之间的潜在关系:结果:20.2%的患者被诊断为CCRT后RIT。ROC 曲线分析确定 68.4 g/dL 为理想的 PIV/Hb 临界值,可有效地将患者分为两组(曲线下面积:94.7%;特异性:86.4%;灵敏度:87.4%)。PIV/Hb > 68 组的 RIT 发生率明显高于 PIV/Hb P < 0.001 组)。多变量逻辑回归分析显示,CCRT前PIV>68与RIT发生率明显较高独立相关:结论:新型 PIV/Hb 指数的预处理水平越高,预示着 LA-NPCs 确诊 CCRT 后的 RIT 率越高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信