Xiaobo Liu, Praneetha Panthagani, Ana G Gutierrez, Arlette Vega, Abdul A Shaik, Monica G Aguilera, Jordan N Sanchez, Joshua O Willms, Brittany Backus, Bruce Blough, Elliott Pauli, Ted W Reid, Thomas Benton, Jeremy D Bailoo, Susan E Bergeson
{"title":"A Pilot Study: Treatment of High Alcohol Consumption in a Novel Minipig Model of Alcohol Use Disorder.","authors":"Xiaobo Liu, Praneetha Panthagani, Ana G Gutierrez, Arlette Vega, Abdul A Shaik, Monica G Aguilera, Jordan N Sanchez, Joshua O Willms, Brittany Backus, Bruce Blough, Elliott Pauli, Ted W Reid, Thomas Benton, Jeremy D Bailoo, Susan E Bergeson","doi":"10.1080/07347324.2024.2355931","DOIUrl":null,"url":null,"abstract":"<p><p>Three medications are FDA approved in the US for treatment of Alcohol Use Disorder (AUD), and a few others are used off-label. Patient compliance and efficacy in the broader population are major hurdles for current AUD medications. As a consequence, there is an urgent need for improved pharmacotherapeutics to complement behavioral approaches. Here, we report pilot testing of a minocycline analog, 10-butylether minocycline (BEM, 10 mg/kg p.o.), in two female minipigs with free-choice drinking to intoxication for nearly two and a half years. Each pig met DSM-5 criteria for diagnosis of severe AUD, and BEM reduced both alcohol intake and preference. BEM is currently undergoing testing for approval as an Investigational New Drug by the FDA for AUD treatment.</p>","PeriodicalId":45949,"journal":{"name":"Alcoholism Treatment Quarterly","volume":"42 4","pages":"393-403"},"PeriodicalIF":0.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463722/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcoholism Treatment Quarterly","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07347324.2024.2355931","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/30 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
引用次数: 0
Abstract
Three medications are FDA approved in the US for treatment of Alcohol Use Disorder (AUD), and a few others are used off-label. Patient compliance and efficacy in the broader population are major hurdles for current AUD medications. As a consequence, there is an urgent need for improved pharmacotherapeutics to complement behavioral approaches. Here, we report pilot testing of a minocycline analog, 10-butylether minocycline (BEM, 10 mg/kg p.o.), in two female minipigs with free-choice drinking to intoxication for nearly two and a half years. Each pig met DSM-5 criteria for diagnosis of severe AUD, and BEM reduced both alcohol intake and preference. BEM is currently undergoing testing for approval as an Investigational New Drug by the FDA for AUD treatment.
期刊介绍：
Alcoholism Treatment Quarterly is an exciting professional journal for clinicians working with persons who are alcoholic and their families. Designed to bridge the gap between research journals and information for the general public, it addresses the specific concerns of professional alcoholism counselors, social workers, psychologists, physicians, clergy, nurses, employee assistance professionals, and others who provide direct services to persons who are alcoholic. The journal features articles specifically related to the treatment of alcoholism, highlighting new and innovative approaches to care, describing clinical problems and solutions, and detailing practical, unique approaches to intervention and therapy.
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