Traumatic Brain Injury Increasing Risk of Meningioma? From the Genetic Evidence.

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

World neurosurgery Pub Date : 2025-01-01 Epub Date: 2024-10-28 DOI:10.1016/j.wneu.2024.10.003

Chunming He, Tao Long, Huaiyu Zhou, Chuan Zeng, Peng Xiong, Xinyu Qiu, Haimin Song

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引用次数: 0

Abstract

Background: Numerous studies have demonstrated a strong association between traumatic brain injury (TBI) and an increased risk of meningioma. However, this correlation remains controversial. This study utilized Mendelian randomization to explore this relationship from the perspective of genetic evidence.

Methods: We employed 6 TBI genome-wide association study datasets from the integrative epidemiology unit genome-wide association study database. Summary statistics for meningioma were sourced from the FinnGen R10 database. We assessed heterogeneity and horizontal pleiotropy within the analyzed data. The primary method was inverse variance weighting (IVW) to investigate the causal relationship between TBI and meningioma, excluding cases with horizontal pleiotropy. Four supplementary analysis methods were also used, with abnormal results excluded based on leave-one-out sensitivity analysis.

Results: All 6 Mendelian randomization analyses indicated no causal relationship between TBI and meningiomas (focal brain injury IVW P value = 0.98; diffuse brain injury IVW P value = 0.41; TBI without concussion IVW P value = 0.45; intracranial trauma IVW P value = 0.34; traumatic subdural hemorrhage IVW P value = 0.80; traumatic subarachnoid hemorrhage IVW P value = 0.92).

Conclusions: The Mendelian randomization study revealed that TBI does not increase the risk of meningioma based on genetic evidence.

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脑外伤增加脑膜瘤风险？遗传学证据

背景：大量研究表明，创伤性脑损伤（TBI）与脑膜瘤风险增加之间存在密切联系。然而，这种相关性仍然存在争议。本研究利用 "泯灭随机化 "方法从遗传学证据的角度探讨了这一关系：我们采用了来自 IEU GWAS 数据库的六个创伤性脑损伤全基因组关联研究（GWAS）数据集。脑膜瘤的汇总统计数据来自芬兰基因 R10 数据库。我们评估了分析数据中的异质性和水平多向性。主要方法是采用反方差加权法（IVW）来研究创伤性脑损伤与脑膜瘤之间的因果关系，同时排除水平多向性的病例。此外，还使用了四种补充分析方法，并根据留一敏感性分析排除了异常结果：六项孟德尔随机分析均表明创伤性脑损伤与脑膜瘤之间没有因果关系（局灶性脑损伤 IVW p 值 = 0.98；弥漫性脑损伤 IVW p 值 = 0.41；无脑震荡的创伤性脑损伤 IVW p 值 = 0.45；颅内创伤 IVW p 值 = 0.34；创伤性硬膜下出血 IVW p 值 = 0.80；创伤性蛛网膜下腔出血 IVW p 值 = 0.92）：孟德尔随机研究表明，根据遗传学证据，脑外伤不会增加脑膜瘤的发病风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World neurosurgery CLINICAL NEUROLOGY-SURGERY

CiteScore

3.90

自引率

15.00%

发文量

1765

审稿时长

47 days

期刊介绍： World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS