SARS-CoV-2 RNAemia as a reliable predictor of long-term mortality among older adults hospitalized in pulmonary intermediate care units: a prospective cohort study.

IF 5.4 3区 材料科学 Q2 CHEMISTRY, PHYSICAL
Ying Liang, Chun Chang, Yanling Ding, Xiaoyan Gai, Hongling Chu, Lin Zeng, Qingtao Zhou, Yongchang Sun
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Abstract

Background: SARS-CoV-2 viremia is associated with disease severity and high risk for in-hospital mortality. However, the impact of SARS-CoV-2 viremia on long-term outcomes in hospitalized patients with COVID-19 is poorly understood.

Methods: We conducted a prospective cohort study and recruited a group of older adult patients with COVID-19 admitted to pulmonary intermediate care units of Peking University Third Hospital during December 2022 and January 2023. The plasma level of SARS-CoV-2 RNA was determined by a standardized RT-PCR technique, and SARS-CoV-2 RNAemia was defined as a plasma viral load ≥ 50 copies/ml. In-hospital and follow-up (180-day) outcome data were collected.

Results: A total of 101 patients with an average of 80.4 years were recruited, and 63.4% of them were severe or very severe cases. Twenty-eight patients (27.7%) had SARS-CoV-2 RNAemia, with a median viral RNA load of 422.1 [261.3, 1085.6] copies/ml. Patients with SARS-CoV-2 RNAemia were more likely to develop critical cases and had a higher incidence of sepsis. Accordingly, they had a higher 180-day mortality (57.1% vs. 19.7%, P < 0.001), as well as in-hospital mortality (50.0% vs. 13.7%, P < 0.001), independent of age, disease severity, sepsis, lymphocyte count and C-Reactive protein. In addition, the risk for 180-day mortality increased with the SARS-CoV-2 RNA load in plasma. Plasma cytokines, including IL-6, IL-8 and IL-10, were higher in patients with SARS-CoV-2 RNAemia.

Conclusions: Our study indicates that SARS-CoV-2 RNAemia serves as a useful biomarker for predicting mortality, especially long-term mortality, in older adult patients hospitalized in pulmonary intermediate care units.

Trial registration: Chinese Clinical Trial Registry website (No. ChiCTR2300067434).

前瞻性队列研究:SARS-CoV-2 RNA 血症是肺病中级护理病房住院老年人长期死亡率的可靠预测指标。
背景:SARS-CoV-2病毒血症与疾病的严重程度和院内死亡的高风险有关。然而,SARS-CoV-2 病毒血症对 COVID-19 住院患者长期预后的影响还不甚了解:方法:我们开展了一项前瞻性队列研究,招募了 2022 年 12 月至 2023 年 1 月期间入住北京大学第三医院肺中级护理病房的 COVID-19 老年患者。血浆中的SARS-CoV-2 RNA水平通过标准化的RT-PCR技术进行测定,血浆病毒载量≥50拷贝/毫升定义为SARS-CoV-2 RNA血症。收集了住院和随访(180 天)结果数据:共招募了 101 名患者,平均年龄为 80.4 岁,其中 63.4% 为重度或极重度病例。28名患者(27.7%)患有SARS-CoV-2 RNA血症,病毒RNA载量中位数为422.1 [261.3, 1085.6]拷贝/毫升。SARS-CoV-2 RNA 血症患者更有可能出现危重病例,败血症的发病率也更高。因此,他们的 180 天死亡率更高(57.1% vs. 19.7%,P 结论:我们的研究表明,SARS-CoV-2 RNA 血症是一种严重的疾病:我们的研究表明,SARS-CoV-2 RNA血症是预测肺部中级护理病房住院老年患者死亡率,尤其是长期死亡率的有效生物标志物:试验注册:中国临床试验注册中心网站(编号:ChiCTR2300067434)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Energy Materials
ACS Applied Energy Materials Materials Science-Materials Chemistry
CiteScore
10.30
自引率
6.20%
发文量
1368
期刊介绍: ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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