Toxicity of coumarins in plant defense against pathogens

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2024-10-05 DOI:10.1016/j.toxicon.2024.108118

Madiha Zaynab , Jallat Khan , Rashid Al-Yahyai , Monther Sadder , Shuangfei Li

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Abstract

Coumarins are a specific type of secondary metabolite that can be found in many plants. These compounds are predominantly produced through the phenylpropanoid pathway. Coumarins have been proven to possess a range of biological activities, including antimicrobial properties and antioxidant functions that aid in plant disease resistance response. The antimicrobial effect of coumarins is achieved through various mechanisms. They disrupt the cell membranes of pathogens, inhibit enzymatic activity, and hinder nucleic acid synthesis. Additionally, coumarins stimulate plant defense responses by triggering the production of reactive oxygen species (ROS) and activating the expression of immunity-related genes and signaling pathways such as the salicylic acid-dependent pathway. Due to their crucial role in defense mechanisms, coumarins can be effectively used in sustainable agriculture practices that emphasize environmentally friendly integrated pest management strategies. By providing a comprehensive overview of the biosynthetic pathways, mode of action, and application of coumarins in plant defense, this review aims to highlight the potential importance of coumarins in developing safe and sustainable crop protection strategies.

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植物防御病原体时香豆素的毒性

香豆素是一种特殊的次级代谢物，可在许多植物中找到。这些化合物主要通过苯丙醇途径产生。香豆素已被证明具有一系列生物活性，包括抗菌特性和抗氧化功能，有助于植物的抗病反应。香豆素的抗菌作用是通过多种机制实现的。它们能破坏病原体的细胞膜，抑制酶的活性，阻碍核酸的合成。此外，香豆素还能引发活性氧（ROS）的产生，激活免疫相关基因和信号途径（如依赖水杨酸的途径）的表达，从而刺激植物的防御反应。由于香豆素在防御机制中的关键作用，它们可以有效地应用于强调环境友好型害虫综合防治策略的可持续农业实践中。本综述全面概述了香豆素的生物合成途径、作用模式以及在植物防御中的应用，旨在强调香豆素在制定安全、可持续的作物保护策略方面的潜在重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

期刊介绍： Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.