Dose and timing effects of caffeine on subsequent sleep: A randomised clinical crossover trial.

IF 5.6 2区 医学 Q1 Medicine
Sleep Pub Date : 2024-10-08 DOI:10.1093/sleep/zsae230
Carissa L Gardiner, Jonathon Weakley, Louise M Burke, Francesca Fernandez, Rich D Johnston, Josh Leota, Suzanna Russell, Gabriella Munteanu, Andrew Townshend, Shona L Halson
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引用次数: 0

Abstract

Study objectives: To investigate the effect of a typical dose of caffeine and a high dose of caffeine consumed in the morning, afternoon, and evening on subsequent sleep.

Methods: Using a placebo-controlled, double-blind, randomised crossover design, 23 males (25.3±5.0 years) with a moderate habitual caffeine intake (<300mg∙day-1) completed seven conditions: placebo, and 100 and 400mg of caffeine consumed 12, eight, and four hours prior to bedtime, with a 48-hour washout. In-home partial polysomnography and sleep diaries were used to assess sleep. Linear mixed models estimated the effect of each condition.

Results: No significant effect on objective or subjective sleep occurred with the 100mg dose of caffeine compared to the placebo (p>0.05) but significant effects occurred with the 400mg dose (p<0.05). Significant delays in sleep initiation and alterations to sleep architecture were observed when 400mg was consumed within 12 hours of bedtime (p<0.05), and significantly greater sleep fragmentation occurred when 400mg was consumed within eight hours of bedtime (p<0.05). Additionally, perceived sleep quality was significantly reduced when 400mg was consumed four hours prior to bedtime (-34.02%, p=.006) but not at eight or 12 hours.

Conclusions: A 100mg dose of caffeine can be consumed up to four hours prior to bedtime, but 400mg may negatively impact sleep when consumed as one dose within 12 hours of bedtime, with the adverse influence on sleep increasing the closer consumption occurs to bedtime. The discrepancy between objective and subjective sleep quality suggests individuals may have difficulty accurately perceiving the influence of caffeine on sleep quality.

咖啡因的剂量和时间对后续睡眠的影响:随机临床交叉试验。
研究目的方法:采用安慰剂对照、双盲、随机交叉设计的方法,对 23 名习惯摄入中等咖啡因的男性(25.3±5.0 岁)进行研究:方法:采用安慰剂对照、双盲、随机交叉设计,23 名男性(25.3±5.0 岁)习惯性摄入适量咖啡因(结果:摄入适量咖啡因后,客观和主观剂量均无显著影响:与安慰剂相比,100 毫克剂量的咖啡因对客观或主观睡眠无明显影响(p>0.05),但 400 毫克剂量的咖啡因对客观或主观睡眠有明显影响(p 结论:100 毫克剂量的咖啡因对客观或主观睡眠无明显影响(p>0.05),但 400 毫克剂量的咖啡因对客观或主观睡眠有明显影响(p>0.05):100毫克剂量的咖啡因可在睡前4小时内摄入,但如果在睡前12小时内一次摄入400毫克剂量的咖啡因,则可能会对睡眠产生负面影响。客观睡眠质量与主观睡眠质量之间的差异表明,个人可能难以准确感知咖啡因对睡眠质量的影响。
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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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