Attenuated melanopsin-mediated post-illumination pupillary response (PIPR) is associated with reduced actigraphic amplitude and mesor in older adults.

IF 5.6 2区 医学 Q1 Medicine
Sleep Pub Date : 2024-10-09 DOI:10.1093/sleep/zsae239
Joey W Y Chan, Chun-Tung Li, Steven Wai Ho Chau, Ngan Yin Chan, Tim Man-Ho Li, Bei Huang, Joshua Tsoh, Shirley X Li, Kelvin K L Chong, Kathryn A Roecklein, Yun Kwok Wing
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Abstract

Study objectives: This study aimed to explore the relationship between post-illumination pupillary response (PIPR) with sleep and circadian measures in a community sample of healthy older adults.

Methods: Eligible participants were invited to complete a one-week sleep diary, actigraphy and provide an overnight urine sample to measure urinary 6-sulfatoxymelatonin (aMT6s). PIPR was defined as the as the pupil constriction at 6s post-stimulus (PIPR-6s), and ii) for 30s beginning 10s after stimulus (PIPR-30s) normalized as a percentage to the baseline pupil diameter, after 1s of blue and 1s of red-light stimulus, respectively. The Net-PIPRs were reported by subtracting the PIPR to red stimulus from the PIPR to blue stimulus. The relationship between PIPR metrics to aMT6s and actigraphic rest-activity rhythm parameters was examined by generalized linear models.

Results: A total of 48 participants were recruited (Mean age: 62.6 ± 7.1 years, Male: 44%). Both Net PIPR-6s and Net PIPR-30s were significantly associated with actigraphic rest-activity amplitude (B=0.03, p=0.001 and B=0.03, p=0.01, respectively), and actigraphic rest-activity mesor (B=0.02, p=0.001 and B=0.03, p=0.004, respectively). Additionally, the Net PIPR-30s were positively associated with overnight aMT6s level (B=0.04, p=0.03), and negatively associated with actigraphic rest-activity acrophase (B=-0.01, p=0.004) in the fully adjusted models.

Conclusion: Attenuated PIPR is associated with a reduced actigraphic amplitude and mesor. The reduced retinal light responsivity may be a potential pathway contributing to impaired photic input to the circadian clock and resulted in the age-related circadian changes in older adults.

黑色素介导的照明后瞳孔反应(PIPR)减弱与老年人的动图振幅和中位数降低有关。
研究目的本研究的目的是在健康老年人的社区样本中,探讨照明后瞳孔反应(PIPR)与睡眠和昼夜节律测量之间的关系:方法:邀请符合条件的参与者填写为期一周的睡眠日记、进行行动测量,并提供隔夜尿样以测量尿液中的 6-磺酸基褪黑素(aMT6s)。PIPR 的定义是:分别在蓝光刺激 1 秒钟和红光刺激 1 秒钟后,刺激后 6 秒钟的瞳孔收缩(PIPR-6s)和刺激后 10 秒钟开始的 30 秒钟的瞳孔收缩(PIPR-30s),归一化为基线瞳孔直径的百分比。净瞳孔指数是用红色刺激的瞳孔指数减去蓝色刺激的瞳孔指数。通过广义线性模型研究了 PIPR 指标与 aMT6s 和行为学静息-活动节律参数之间的关系:共招募了 48 名参与者(平均年龄:62.6 ± 7.1 岁,男性:44%)。净PIPR-6s和净PIPR-30s均与动图静息活动振幅(分别为B=0.03,p=0.001和B=0.03,p=0.01)和动图静息活动介度(分别为B=0.02,p=0.001和B=0.03,p=0.004)显著相关。此外,在完全调整模型中,PIPR-30 净值与隔夜 aMT6s 水平呈正相关(B=0.04,p=0.03),与动图静息活动尖相呈负相关(B=-0.01,p=0.004):结论:PIPR减弱与动图振幅和中位数降低有关。视网膜光反应性降低可能是导致昼夜节律钟光输入受损的潜在途径,并导致老年人出现与年龄相关的昼夜节律变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sleep
Sleep Medicine-Neurology (clinical)
CiteScore
8.70
自引率
10.70%
发文量
0
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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