Nasopharyngeal mucoepidermoid carcinoma with mastermind-like transcriptional coactivator 2 translocation: A case report and comprehensive literature review of a rare entity.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

SAGE Open Medical Case Reports Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI:10.1177/2050313X241281323

Chan-Fong Chio, Wan-Pang Sam, Sio-In Wong, Cheong-Un Sio, Lai-Fong Kok, Ki-Man Pai, Thazin Hlaing

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引用次数: 0

Abstract

Mucoepidermoid carcinoma is one of the most common malignant tumors in salivary glands and is usually associated with mastermind-like transcriptional coactivator 2 (MAML2) rearrangement. Primary nasopharyngeal mucoepidermoid carcinoma is extremely rare, and MAML2 status was reported in only two studies. Herein, we present a 70-year-old male patient with incidentally found nasopharyngeal mucoepidermoid carcinoma. MAML2 translocation was detected by fluorescence in situ hybridization test. Additionally, we conducted a comprehensive literature review and summarized the clinicopathological features of this rare condition. Nasopharyngeal mucoepidermoid carcinoma shows a similar mean age at diagnosis and gender ratio to those of mucoepidermoid carcinoma in salivary glands. More than half of the patients exhibit high histologic grade at the time of diagnosis. As MAML2 status is unreported in almost all published cases, further studies are needed to explore the incidence and prognostic value of MAML2 rearrangement in nasopharyngeal mucoepidermoid carcinoma.

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鼻咽粘液表皮样癌伴有主脑样转录辅激活剂 2 易位：一例罕见病例的病例报告和文献综述。

粘液表皮样癌是唾液腺中最常见的恶性肿瘤之一，通常与主脑样转录辅激活子2（MAML2）重排有关。原发性鼻咽粘液表皮样癌极为罕见，仅有两项研究报告了其 MAML2 状态。在此，我们介绍了一名偶然发现鼻咽粘液鳞状细胞癌的 70 岁男性患者。荧光原位杂交检测发现了 MAML2 易位。此外，我们还进行了全面的文献综述，总结了这种罕见疾病的临床病理特征。鼻咽粘液表皮样癌的平均诊断年龄和性别比例与唾液腺粘液表皮样癌相似。一半以上的患者在确诊时组织学分级较高。由于几乎所有已发表的病例都未报告MAML2状态，因此需要进一步研究鼻咽粘液样表皮样癌中MAML2重排的发生率和预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

SAGE Open Medical Case Reports MEDICINE, GENERAL & INTERNAL-

CiteScore

0.60

自引率

0.00%

发文量

320

审稿时长

8 weeks

期刊介绍： SAGE Open Medical Case Reports (indexed in PubMed Central) is a peer reviewed, open access journal. It aims to provide a publication home for short case reports and case series, which often do not find a place in traditional primary research journals, but provide key insights into real medical cases that are essential for physicians, and may ultimately help to improve patient outcomes. SAGE Open Medical Case Reports does not limit content due to page budgets or thematic significance. Papers are subject to rigorous peer review and are selected on the basis of whether the research is sound and deserves publication. By virtue of not restricting papers to a narrow discipline, SAGE Open Medical Case Reports facilitates the discovery of the connections between papers, whether within or between disciplines. Case reports can span the full spectrum of medicine across the health sciences in the broadest sense, including: Allergy/Immunology Anaesthesia/Pain Cardiovascular Critical Care/ Emergency Medicine Dentistry Dermatology Diabetes/Endocrinology Epidemiology/Public Health Gastroenterology/Hepatology Geriatrics/Gerontology Haematology Infectious Diseases Mental Health/Psychiatry Nephrology Neurology Nursing Obstetrics/Gynaecology Oncology Ophthalmology Orthopaedics/Rehabilitation/Occupational Therapy Otolaryngology Palliative Medicine Pathology Pharmacoeconomics/health economics Pharmacoepidemiology/Drug safety Psychopharmacology Radiology Respiratory Medicine Rheumatology/ Clinical Immunology Sports Medicine Surgery Toxicology Urology Women''s Health.