Interaction between tea consumption and genes on activities of daily living disability in older adults.

IF 1.3 4区心理学 Q3 PSYCHOLOGY, MULTIDISCIPLINARY

PsyCh journal Pub Date : 2024-10-07 DOI:10.1002/pchj.801

Min Zou, Mengxue Yang, Dewei Zheng, Changlong Sun, Jiali Wang, Xiaoping Yuan, Changjiang Li, Lirong Yu, Lina Sun, Yanyu Wang, Huashuai Chen, Yi Zeng

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引用次数: 0

Abstract

The effects of tea consumption on delaying aging and the onset of age-related disabilities have been reported; however, it is unclear whether these benefits are impacted by genes. This study aimed to examine the associations between tea consumption and activities of daily living (ADL) and explore the role of genetic factors. Data from 46,487 older adults aged 64-105 who participated in at least one data wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted in 2002, 2005, 2008, 2011, 2014, and 2018 were analyzed. Genetic data were produced using the Affymetrix Axiom™myDesign™ (384-format) Human Genotyping Array. The generalized estimation equation and multiple logistic regression models were constructed to examine the effects of tea consumption, polygenic risk score, and their interactions on ADL. Tea consumption was related to reduced ADL decline-the effect was statistically significant among men but not women. A significant interaction between tea consumption and polygenic risk score (PRS) was observed. Tea consumption was associated with a decreased risk of ADL disability only among individuals with a low PRS. These findings indicate that tea consumption plays a role in preventing disability in older adults with low polygenic risk.

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饮茶量与老年人日常生活障碍基因之间的相互作用。

有报道称，饮茶可延缓衰老和老年性残疾的发生，但这些益处是否受基因的影响尚不清楚。本研究旨在研究饮茶与日常生活活动（ADL）之间的关系，并探讨遗传因素的作用。研究分析了 46,487 名年龄在 64-105 岁之间的老年人的数据，他们至少参加了 2002 年、2005 年、2008 年、2011 年、2014 年和 2018 年进行的中国健康长寿纵向调查（CLHLS）的一个数据波。基因数据使用 Affymetrix Axiom™myDesign™（384 格式）人类基因分型阵列生成。建立了广义估计方程和多元逻辑回归模型，以检验饮茶量、多基因风险评分及其相互作用对ADL的影响。饮茶与ADL下降有关--男性饮茶对ADL下降的影响具有统计学意义，而女性饮茶对ADL下降的影响不具有统计学意义。饮茶量与多基因风险评分（PRS）之间存在明显的交互作用。只有在PRS较低的个体中，饮茶才与ADL残疾风险的降低有关。这些研究结果表明，对于多基因风险较低的老年人来说，饮茶可起到预防残疾的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PsyCh journal PSYCHOLOGY, MULTIDISCIPLINARY-

CiteScore

2.70

自引率

12.50%

发文量

109

期刊介绍： PsyCh Journal, China''s first international psychology journal, publishes peer‑reviewed research articles, research reports and integrated research reviews spanning the entire spectrum of scientific psychology and its applications. PsyCh Journal is the flagship journal of the Institute of Psychology, Chinese Academy of Sciences – the only national psychology research institute in China – and reflects the high research standards of the nation. Launched in 2012, PsyCh Journal is devoted to the publication of advanced research exploring basic mechanisms of the human mind and behavior, and delivering scientific knowledge to enhance understanding of culture and society. Towards that broader goal, the Journal will provide a forum for academic exchange and a “knowledge bridge” between China and the World by showcasing high-quality, cutting-edge research related to the science and practice of psychology both within and outside of China. PsyCh Journal features original articles of both empirical and theoretical research in scientific psychology and interdisciplinary sciences, across all levels, from molecular, cellular and system, to individual, group and society. The Journal also publishes evaluative and integrative review papers on any significant research contribution in any area of scientific psychology