Does serum albumin at the onset of necrotisıng enterocolitis predict severe disease in preterm infants?

IF 1.5 3区医学 Q2 PEDIATRICS

Pediatric Surgery International Pub Date : 2024-10-09 DOI:10.1007/s00383-024-05850-6

Gökçe Çıplak, Fatma Nur Sarı, Elif Emel Erten, Müjdem Nur Azılı, Süleyman Arif Bostancı, Cüneyt Tayman, Evrim Alyamaç Dizdar, Emrah Şenel

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引用次数: 0

Abstract

Objective: To investigate whether laboratory markers obtained at the onset of necrotising enterocolitis (NEC) predict the severity of the disease in preterm infants.

Methods: Prospective cohort study conducted in a tertiary referance hospital. A total of 88 preterm infants were included in the study. Of those, 60 infants had the diagnosis of severe NEC, while the remaining 28 infants constituted the non-severe NEC group. Severe NEC was defined as surgical NEC or NEC-related mortality. Infants with and without severe NEC were compared in terms of demographic, clinical and laboratory characteristics.

Results: At the onset of disease, infants with severe NEC noted to have lower platelet count and serum ALB levels (p = 0.011, p = 0.004; respectively), whereas higher CRP, and serum lactate levels (p = 0.009, p = 0.008; respectively). Multiple binary logistic regression analyses showed that CRP (1.03(1.01-1.05), p = 0.024) and serum albumin level (0.16(0.04-0.64), p = 0.010) were statistically significant independent risk factors for severe NEC. The optimal cut-off value for the serum ALB level was found to be 23 g/L with 52% sensitivity (95%CI: 37-68%) and 84% specificity (95%CI: 60-97%) (AUC 0.727; p = 0.002).

Conclusion: Serum ALB level at NEC onset might be a reliable biomarker for severe disease in preterm infants.

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坏死性小肠结肠炎发病时的血清白蛋白能否预测早产儿的严重病情？

目的研究坏死性小肠结肠炎（NEC）发病时获得的实验室标记物能否预测早产儿病情的严重程度：方法：在一家三级转诊医院进行前瞻性队列研究。研究共纳入 88 名早产儿。其中 60 名婴儿被诊断为重度 NEC，其余 28 名婴儿为非重度 NEC 组。严重 NEC 的定义是手术 NEC 或 NEC 相关死亡。对患有和未患有严重NEC的婴儿在人口统计学、临床和实验室特征方面进行了比较：结果：在发病时，重度 NEC 婴儿的血小板计数和血清 ALB 水平较低（分别为 p = 0.011 和 p = 0.004），而 CRP 和血清乳酸盐水平较高（分别为 p = 0.009 和 p = 0.008）。多元二元逻辑回归分析表明，CRP（1.03（1.01-1.05），p = 0.024）和血清白蛋白水平（0.16（0.04-0.64），p = 0.010）是严重 NEC 的具有统计学意义的独立危险因素。研究发现，血清 ALB 水平的最佳临界值为 23 g/L，敏感性为 52%（95%CI：37-68%），特异性为 84%（95%CI：60-97%）（AUC 0.727；p = 0.002）：结论：NEC发病时的血清ALB水平可能是早产儿严重疾病的可靠生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Surgery International 医学-外科

CiteScore

3.00

自引率

5.60%

发文量

215

审稿时长

3-6 weeks

期刊介绍： Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children. The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include: -Review articles- Original articles- Technical innovations- Letters to the editor