Outcomes in Minor Salivary Gland Tumors-A 20+ Year Tertiary-Care Center Experience.

IF 1.8 Q2 OTORHINOLARYNGOLOGY

OTO Open Pub Date : 2024-10-08 eCollection Date: 2024-10-01 DOI:10.1002/oto2.70030

Emily S Zhang, Samuel Doty, Neil Woody, Danielle Bottalico, Jamie A Ku, Brandon Prendes, Shlomo A Koyfman, Shauna R Campbell, Natalie Silver, Joseph Scharpf, Eric D Lamarre

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Abstract

Objective: Minor salivary gland carcinomas are challenging to study due to their rarity and heterogeneity. We aim to further characterize clinical characteristics, treatment, and outcomes over 20 years within a single institution.

Study design: Retrospective chart review was conducted on 210 patients who received primary treatment for minor salivary gland malignancy from 2000 to 2022.

Setting: Single tertiary-care center.

Methods: Multivariable Cox proportional hazards method was used to examine the relationship between pre-determined clinically important variables and outcomes.

Results: Five-year overall survival was 77.8% (72.0-84.1). Advanced clinical T stage portended over a 2 times higher risk of death and recurrence. High pathologic grade was associated with a near 3 times higher risk of death and recurrence. There was a predominance of occult nodal metastases in level II for oral cavity and oropharynx site tumors.

Conclusion: Clinical T stage and grade were important for overall survival, local, regional, and distant recurrence-free survival. Occult nodal metastases occurred most often in level II.

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轻微唾液腺肿瘤的疗效--20 多年三级医疗中心的经验。

目的：小唾液腺癌由于其罕见性和异质性，研究难度很大。我们的目的是进一步描述一家机构 20 年来的临床特征、治疗方法和结果：研究设计：对2000年至2022年期间接受初级治疗的210例轻微唾液腺恶性肿瘤患者进行回顾性病历审查：单一三级医疗中心：方法：采用多变量考克斯比例危险度法研究预先确定的临床重要变量与结果之间的关系：五年总生存率为77.8%（72.0-84.1）。临床T期晚期的死亡和复发风险高出2倍以上。病理分级高的患者死亡和复发的风险高出近 3 倍。在口腔和口咽部位肿瘤中，Ⅱ级肿瘤以隐匿性结节转移为主：结论：临床T分期和分级对总生存率、局部、区域和远处无复发生存率非常重要。隐匿性结节转移最常发生在 II 级。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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