Sensory neuroimmune interactions at the barrier.

IF 7.9 2区 医学 Q1 IMMUNOLOGY
Zhen Wang, Keaton Song, Brian S Kim, John Manion
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引用次数: 0

Abstract

Epithelial barriers such as the skin, lung, and gut, in addition to having unique physiologic functions, are designed to preserve tissue homeostasis upon challenge with a variety of allergens, irritants, or pathogens. Both the innate and adaptive immune systems play a critical role in responding to epithelial cues triggered by environmental stimuli. However, the mechanisms by which organs sense and coordinate complex epithelial, stromal, and immune responses have remained a mystery. Our increasing understanding of the anatomic and functional characteristics of the sensory nervous system is greatly advancing a new field of peripheral neuroimmunology and subsequently changing our understanding of mucosal immunology. Herein, we detail how sensory biology is informing mucosal neuroimmunology, even beyond neuroimmune interactions seen within the central and autonomic nervous systems.

屏障上的感官神经免疫相互作用
皮肤、肺部和肠道等上皮屏障除了具有独特的生理功能外,还能在受到各种过敏原、刺激物或病原体的挑战时保持组织平衡。先天性免疫系统和适应性免疫系统在对环境刺激引发的上皮线索做出反应方面都起着至关重要的作用。然而,器官感知和协调复杂的上皮、基质和免疫反应的机制一直是个谜。我们对感觉神经系统的解剖和功能特征的理解不断加深,这极大地推动了外周神经免疫学这一新领域的发展,并随之改变了我们对粘膜免疫学的理解。在此,我们将详细介绍感觉生物学如何为粘膜神经免疫学提供信息,甚至超越中枢神经系统和自主神经系统内的神经免疫相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mucosal Immunology
Mucosal Immunology 医学-免疫学
CiteScore
16.60
自引率
3.80%
发文量
100
审稿时长
12 days
期刊介绍: Mucosal Immunology, the official publication of the Society of Mucosal Immunology (SMI), serves as a forum for both basic and clinical scientists to discuss immunity and inflammation involving mucosal tissues. It covers gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through original research articles, scholarly reviews, commentaries, editorials, and letters. The journal gives equal consideration to basic, translational, and clinical studies and also serves as a primary communication channel for the SMI governing board and its members, featuring society news, meeting announcements, policy discussions, and job/training opportunities advertisements.
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