Tilianin obtained from Agastache mexicana inhibits monoamine oxidase and modifies depressive behavior in rats.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmacy and Pharmacology Pub Date : 2024-10-07 DOI:10.1093/jpp/rgae117

Edgar Rodríguez-Wilson, Samuel Estrada-Soto, Moisés Rubio-Osornio, Luis Tristán-López, Gabriel Navarrete-Vázquez, Abraham Gutiérrez-Hernández, Sergio Montes

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引用次数: 0

Abstract

Background: Agastache mexicana is used in traditional medicine to treat anxiety, insomnia, pain, among others. In a previous study, the methanolic extract exerted anxiolytic and sedative effects, as observed behaviorally, associated with one of its major components, tilianin.

Objective: To assess the effect produced by the extracts and tilianin obtained from Agastache mexicana on depressive-induced behavior model and on the activity of monoamine oxidases (MAOs).

Methods: The depression experimental model consisted of the forced swimming test in rats. MAOs activity was evaluated in cortex and hippocampus from the tilianin and Agastache extracts treated rats using specific inhibitors for each isoform. The quantification of monoamines was carried out using an High Performance Liquid Chromatography method.

Results: An increase in the swimming time was observed in rodents treated with doses of 16 (226.6 ± 5.5 seconds) and 50 mg/kg (237.8 ± 5.7 seconds) of tilianin, methanolic (260.4 ± 3 seconds), and hydroalcoholic extracts (249.6 ± 2.6 seconds) at 100 mg/kg. MAOs activity was significantly decreased in brain tissue from animals treated with 16 and 50 mg/kg of tilianin, methanolic, and hydroalcoholic extracts at 100 mg/kg.

Conclusions: The tilianin effect on monoamine oxidases inhibition is confirmed, suggesting its potential use in the treatment of certain neurological disorders.

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从 Agastache mexicana 中提取的 Tilianin 可抑制单胺氧化酶并改变大鼠的抑郁行为。

背景：Agastache mexicana在传统医学中被用于治疗焦虑、失眠、疼痛等。在之前的一项研究中，甲醇提取物产生了抗焦虑和镇静作用，通过行为观察发现，这与其主要成分之一的tilianin有关：目的：评估墨西哥龙葵提取物和龙葵素对抑郁诱导行为模型和单胺氧化酶（MAOs）活性的影响：抑郁实验模型包括大鼠强迫游泳试验。方法：抑郁实验模型包括大鼠强迫游泳测试，使用针对每种同工酶的特异性抑制剂评估了经 tilianin 和 Agastache 提取物处理的大鼠大脑皮层和海马的 MAOs 活性。采用高效液相色谱法对单胺类物质进行了定量分析：结果：用 16 毫克/千克（226.6 ± 5.5 秒）和 50 毫克/千克（237.8 ± 5.7 秒）的提拉宁、甲醇提取物（260.4 ± 3 秒）和 100 毫克/千克的水醇提取物（249.6 ± 2.6 秒）处理啮齿动物，观察到其游泳时间增加。用 16 毫克和 50 毫克/千克的罗汉果苷、甲醇提取物和 100 毫克/千克的水醇提取物处理动物脑组织后，MAOs 活性明显降低：结论：蒂利亚宁对单胺氧化酶的抑制作用已得到证实，这表明它可用于治疗某些神经系统疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmacy and Pharmacology 医学-药学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.