Application of Optical Coherence Tomography Angiography in True and Pseudo-Optic Disc Swelling.

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY
Journal of Ophthalmology Pub Date : 2024-09-30 eCollection Date: 2024-01-01 DOI:10.1155/2024/1164635
Kaveh Abri Aghdam, Ali Aghajani, Amin Zand, Samira Chaibakhsh, Pasha Anvari, Fatemeh Zahra Ijadi, Khalil Ghasemi Falavarjani
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引用次数: 0

Abstract

Purpose: We evaluated the optic disc microvasculature in healthy subjects and patients with optic nerve head drusen (ONHD), active papilledema, and acute nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA).

Methods: This prospective, comparative case series included sixteen eyes with ONHD, thirty-one eyes with active papilledema, sixteen eyes with acute NAION, and thirty-two healthy eyes. The Optovue AngioVue OCT and OCTA Imaging System recorded peripapillary retinal nerve fiber layer (RNFL) thickness and vessel density maps from the radial peripapillary capillary (RPC) slab.

Results: Average RNFL thicknesses were greater in eyes with ONHD, papilledema, and NAION compared to control eyes (all Ps < 0.001), but this parameter did not differ among patient groups. The mean peripapillary vessel density did not differ between the ONHD and control groups (P=1.000), nor between the NAION and papilledema groups (P=0.216). However, this value in the ONHD and control groups was significantly higher than in the NAION and papilledema groups (all Ps < 0.05).

Conclusion: RPC density is influenced during the progression of conditions such as ONHD, papilledema, and NAION. Although a decrease in vessel density values has been observed in cases of true disc edema, further research is necessary to assess the potential of OCTA in differentiating between true and pseudo-optic disc edema.

光学相干断层扫描血管造影在真性和假性椎间盘肿胀中的应用。
目的:我们使用光学相干断层血管造影(OCTA)评估了健康受试者和视神经头色素沉着(ONHD)、活动性乳头水肿和急性非动脉炎性前部缺血性视神经病变(NAION)患者的视盘微血管:该前瞻性对比病例系列包括 16 只 ONHD 眼、31 只活动性乳头水肿眼、16 只急性 NAION 眼和 32 只健康眼。Optovue AngioVue OCT 和 OCTA 成像系统记录了毛细血管周围视网膜神经纤维层(RNFL)厚度和来自毛细血管径向周围(RPC)板的血管密度图:结果:与对照眼相比,ONHD、乳头水肿和NAION患者的平均RNFL厚度更大(Ps均<0.001),但这一参数在不同患者组之间没有差异。ONHD组和对照组之间的毛细血管平均密度没有差异(P=1.000),NAION组和乳头水肿组之间的毛细血管平均密度也没有差异(P=0.216)。然而,ONHD组和对照组的这一数值明显高于NAION组和乳头水肿组(所有Ps均<0.05):结论:RPC 密度在 ONHD、乳头水肿和 NAION 等疾病的发展过程中会受到影响。尽管在真正的视盘水肿病例中观察到血管密度值下降,但仍有必要开展进一步研究,以评估 OCTA 在区分真正的视盘水肿和假性视盘水肿方面的潜力。
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来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
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