Extensive Genomic Rearrangement of Catalase-Less Cyanobloom-Forming Microcystis aeruginosa in Freshwater Ecosystems.

IF 3.3 4区 生物学 Q2 MICROBIOLOGY
Journal of Microbiology Pub Date : 2024-11-01 Epub Date: 2024-10-08 DOI:10.1007/s12275-024-00172-7
Minkyung Kim, Jaejoon Jung, Wonjae Kim, Yerim Park, Che Ok Jeon, Woojun Park
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引用次数: 0

Abstract

Many of the world's freshwater ecosystems suffer from cyanobacteria-mediated blooms and their toxins. However, a mechanistic understanding of why and how Microcystis aeruginosa dominates over other freshwater cyanobacteria during warmer summers is lacking. This paper utilizes comparative genomics with other cyanobacteria and literature reviews to predict the gene functions and genomic architectures of M. aeruginosa based on complete genomes. The primary aim is to understand this species' survival and competitive strategies in warmer freshwater environments. M. aeruginosa strains exhibiting a high proportion of insertion sequences (~ 11%) possess genomic structures with low synteny across different strains. This indicates the occurrence of extensive genomic rearrangements and the presence of many possible diverse genotypes that result in greater population heterogeneities than those in other cyanobacteria in order to increase survivability during rapidly changing and threatening environmental challenges. Catalase-less M. aeruginosa strains are even vulnerable to low light intensity in freshwater environments with strong ultraviolet radiation. However, they can continuously grow with the help of various defense genes (e.g., egtBD, cruA, and mysABCD) and associated bacteria. The strong defense strategies against biological threats (e.g., antagonistic bacteria, protozoa, and cyanophages) are attributed to dense exopolysaccharide (EPS)-mediated aggregate formation with efficient buoyancy and the secondary metabolites of M. aeruginosa cells. Our review with extensive genome analysis suggests that the ecological vulnerability of M. aeruginosa cells can be overcome by diverse genotypes, secondary defense metabolites, reinforced EPS, and associated bacteria.

淡水生态系统中形成无催化酶蓝藻的铜绿微囊藻的广泛基因组重排。
世界上许多淡水生态系统都受到蓝藻介导的水华及其毒素的影响。然而,人们对铜绿微囊藻为何以及如何在较温暖的夏季支配其他淡水蓝藻缺乏机理上的了解。本文利用与其他蓝藻的比较基因组学和文献综述,在完整基因组的基础上预测铜绿微囊藻的基因功能和基因组结构。主要目的是了解该物种在较暖淡水环境中的生存和竞争策略。铜绿微囊藻菌株的插入序列比例较高(约 11%),不同菌株的基因组结构同源性较低。这表明铜绿微囊藻发生了广泛的基因组重排,并存在许多可能的不同基因型,与其他蓝藻相比,其种群异质性更大,以便在瞬息万变、充满威胁的环境挑战中提高生存能力。不含过氧化氢酶的铜绿微囊藻菌株在紫外线辐射强烈的淡水环境中甚至容易受到低光照强度的影响。然而,在各种防御基因(如 egtBD、cruA 和 mysABCD)和相关细菌的帮助下,它们可以继续生长。铜绿微囊藻细胞对生物威胁(如拮抗细菌、原生动物和噬蓝藻病毒)的强大防御策略归功于由致密外多糖(EPS)介导的具有高效浮力的聚合体形成和次生代谢产物。我们的综述和大量基因组分析表明,铜绿微囊藻细胞的生态脆弱性可以通过不同的基因型、次生防御代谢物、强化的 EPS 和相关细菌来克服。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Microbiology
Journal of Microbiology 生物-微生物学
CiteScore
5.70
自引率
3.30%
发文量
0
审稿时长
3 months
期刊介绍: Publishes papers that deal with research on microorganisms, including archaea, bacteria, yeasts, fungi, microalgae, protozoa, and simple eukaryotic microorganisms. Topics considered for publication include Microbial Systematics, Evolutionary Microbiology, Microbial Ecology, Environmental Microbiology, Microbial Genetics, Genomics, Molecular Biology, Microbial Physiology, Biochemistry, Microbial Pathogenesis, Host-Microbe Interaction, Systems Microbiology, Synthetic Microbiology, Bioinformatics and Virology. Manuscripts dealing with simple identification of microorganism(s), cloning of a known gene and its expression in a microbial host, and clinical statistics will not be considered for publication by JM.
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