Transforming growth factor-β in tumor microenvironment: Understanding its impact on monocytes and macrophages for its targeting.

IF 4.3 4区医学 Q2 IMMUNOLOGY

International Reviews of Immunology Pub Date : 2024-10-08 DOI:10.1080/08830185.2024.2411998

Tetiana Hourani, Amit Sharma, Rodney B Luwor, Adrian A Achuthan

引用次数: 0

Abstract

TGF-β is a pivotal cytokine that orchestrates various aspects of cancer progression, including tumor growth, metastasis, and immune evasion. In this review, we present a comprehensive overview of the multifaceted role of transforming growth factor β (TGF-β) in cancer biology, focusing on its intricate interactions with monocytes and macrophages within the tumor microenvironment (TME). We specifically discuss how TGF-β modulates monocyte and macrophage activities, leading to immunosuppression and tumor progression. We conclude with the current translational and clinical efforts targeting TGF-β, recognizing the promising role of this strategy in immunooncology.

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肿瘤微环境中的转化生长因子-β：了解其对单核细胞和巨噬细胞的影响，以实现靶向治疗。

TGF-β 是一种关键的细胞因子，它协调着癌症进展的各个方面，包括肿瘤生长、转移和免疫逃避。在这篇综述中，我们全面概述了转化生长因子 β（TGF-β）在癌症生物学中的多方面作用，重点是它与肿瘤微环境（TME）中的单核细胞和巨噬细胞之间错综复杂的相互作用。我们将具体讨论 TGF-β 如何调节单核细胞和巨噬细胞的活动，从而导致免疫抑制和肿瘤进展。最后，我们介绍了目前以 TGF-β 为靶点的转化和临床工作，认识到这一策略在免疫肿瘤学中大有可为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).